Fmc Corporation

Debra A Yuhas

Blaik P Halling

Provided, among other things, is an isolated nucleic acid encoding a GABA-gated chloride channel having: (a) a nucleic acid including a sequence encoding a protein sequence of SEQ ID NO: 3, SEQ ID NO: 6 or SEQ ID NO: 8, or a sequence having at least about 85% sequence identity with SEQ ID NO: 3, SEQ ID NO: 6 or SEQ ID NO: 8, or (b) a nucleic acid that hybridizes with a nucleic acid encoding a protein sequence of SEQ ID NO: 3, SEQ ID NO: 6 or SEQ ID NO: 8 or the complementary sequence to SEQ ID NO: 3, SEQ ID NO: 6 or SEQ ID NO: 8, under stringent conditions; or (c) a nucleic acid that hybridizes with a nucleic acid having a sequence of SEQ ID NO: 1, SEQ ID NO: 4 or SEQ ID NO: 7 or the complementary sequence to SEQ ID NO: 1, SEQ ID NO: 4 or SEQ ID NO: 7, under stringent conditions; or (d) a nucleic acid has at least about 85% sequence identity with the coding region of SEQ ID NO: 1, SEQ ID NO: 4 or SEQ ID NO: 7.

Lepidopteran GABA-gated chloride channels

Disclosed is a method and a pharmaceutical composition for killing mammalian tumor cells by subjecting the cells to light in the presence of a light-activatable tetrapyrrole, in which the improvement comprises treating the cells with a compound which inhibits the enzymatic conversion of protoporphyrinogen to protoporphyrin IX by protoporphyrinogen oxidase in the cells thereby causing a buildup of protoporphyrin IX in the cells. Also disclosed is a method for the production of protoporphyrin IX which comprises growing eukaryotic microalgae in the presence of a protoporphyrinogen oxidase inhibitor.

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Wrightstown, NJ, United States of America

Debra A Yuhas