Smithkline Beecham Corporation

Deborah Wild

Brian Cox

Mark Patrick Healy

A compound of formula (I) wherein R is phenyl substituted by one or more halogen atoms; R is &mdash;NH ; R is &mdash;NH or hydrogen; R is &mdash;CXNR R , &mdash;CXNH&mdash;(CH ) &mdash;NR R ; wherein X is &boxH;O or &plus;S; y is an integer zero, 1 or 2; R and R , which may be the same or different, are selected from hydrogen and C alkyl or together with the nitrogen atom to which they are attached form a saturated 5- or 6-membered heterocycle containing one or two nitrogen heteroatoms, which heterocycle can be further substituted with one or more C alkyl groups; and pharmaceutically acceptable derivatives thereof.

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Stevenage, United Kingdom

Deborah Wild