United Therapeutics Corporation

Deborah Strootman

Roger Andrew Jeffs

Michael Wade

Roger Jeffs

Kathryn Bronstein

Robert Roscigno

The present disclosure relates to novel methods for using treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of ischemic lesions, such as digital ulcers, in subjects with scleroderma (including systemic sclerosis), Buerger's disease, Raynaud's disease, Raynaud's phenomenon and/or other conditions that cause such lesions. The disclosure also relates to kits for treatment and/or prevention of ischemic lesions, which include an effective amount of treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.

Use of treprostinil to treat and prevent ischemic lesions

The present invention describes novel methods for using 9-deoxy-2',9-&#x3b1;-methano-3-oxa-4,5,6-trinor-3,7-(1&#x2032;,3&#x2032;-interphenylene)-13,14-dihydro-prostaglandin F(also known as Treprostinil) or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of foot ulcers in subjects with diabetic neuropathy. The invention also relates to kits for treatment and/or prevention of foot ulcers, comprising an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.

Use of treprostinil to treat neuropathic diabetic foot ulcers

Use of Treprostinil to treat neuropathic diabetic foot ulcers

The present invention describes novel methods for using Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for improving kidney functions, such as urine output, and treating symptoms associated with kidney malfunction or failure. The invention also relates to kits for the improvement of kidney functions and the treatment of symptoms associated with kidney malfunction or failure, comprising an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.

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Tucson, AZ, United States of America

Deborah Strootman