Glaxo Group Limited

Glaxosmithkline Intellectual Property Development Limited

Deborah Needham

Keith Biggadike

Diane Mary Coe

Daniel Terence Tape

Aurelie Cecile Champigny

Panayiotis Alexandrou Procopiou

Nigel James Parr

Timothy John Ritchie

Simon Teanby Hodgson

Heather Hobbs

Michael David Woodrow

Gianpaolo Bravi

Matthew Peter John

Yannick Maurice Lacroix

A compound of formula (1) Or a pharmaceutically acceptable salt and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases and conditions in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer and as vaccine adjuvants.

Cyclic di-nucleotides as modulators of STING

A compound of formula (I) or a pharmaceutically acceptable salt and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases and conditions in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer, pre-cancerous syndromes and as vaccine adjuvants.

Cyclic dinucleotides useful for the treatment of inter alia cancer

A compound of formula (I) wherein or a pharmaceutically acceptable salt thereof.

N-cyclobutyl-imidazopyridine-methylamine as TRPV1 antagonists

Indazole compounds, processes for their preparation, intermediates usable in these processes, pharmaceutical compositions containing such compounds and their use in therapy.

Pyrazole derivatives used as CCR4 receptor antagonists

Glucocorticosteroid compound having anti-inflammatory activity

The present invention is directed to compounds of formula (I): wherein

Androstane 17&#x3b1;-carbonate derivatives for use in the treatment of allergic and inflammatory conditions

A compound of formula (I): or a physiologically acceptable solvate thereof.

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Stevenage, United Kingdom

Deborah Needham