Kansas State University Research Foundation

Deborah Jaworski

Roman Reddy Ganta

Arathy D S Nair

Chuanmin Cheng

Suhasini Ganta

Attenuated vaccines to protect vertebrate animals and people against tick-born rickettsial,andspecies infections is disclosed. Also disclosed are methods to modify the organism to achieve the desired immunity through the modification of a novel genetic region involved in pathogenesis. These compounds represent a needed vaccine against an organism causing life-threatening febrile illness in humans and animals, and also represent the potential to develop new classes of drugs targeting the gene products of genes Ech_0379 and Ech_0230, and their homologs of other related rickettsial pathogens.

Attenuated vaccines to protect against tick-bornespecies infections

Attenuated vaccines to protect vertebrate animals and people against tick-born rickettsial,andspecies infections is disclosed. Also disclosed are methods to modify the organism to achieve the desired immunity through the modification of a novel genetic region involved in pathogenesis. These compounds represent a needed vaccine against an organism causing life-threatening febrile illness in humans and animals, and also represent the potential to develop new classes of drugs targeting the gene products of genes Ech_0660, Ech_0379, and Ech_0230, and their homologs of other related rickettsial pathogens.

Growing community of inventors

Stillwater, OK, United States of America

Deborah Jaworski