The University of Chicago

University of Pittsburgh

Washington University

The United States Government As Represented by the Department of Veterans Affairs

Manros Therapeutics

Deborah J Nelson

Laurent Meijer

Paul H Schlesinger

Nassima Oumata

Harry Colbert Blair

Hervé Galons

Quitterie Larrouture

Aida Gabdoulkhakova

Irina L Tourkova

Vladimir Riazanski

Provided herein are methods of producing trabecular bone material, such as trabecular bone or trabecular bone matrix and cells useful in preparing the trabecular bone material.

Method of making trabecular bone

A method for treatment of disease by reduction in macrophages-mediated bacterial killing, including administration to patients in need a compound of formula (I): wherein A is N or CH; B is NO, or S; Ris H, (C-C)alkyl group, methyl(C-C)cycloalkyl group or (C-C)cycloalkyl group; Ris an aryl, arylmethyl group or methylheteroaryl group as methylpyridine and methylthiophene; Ris absent when B is O or S, or is H or (C-C)alkyl group when B is N; Ris (C-C)alkyl group or (C-C)cycloalkyl group, groups bearing a carboxylic acid group, and (C-C)alkyl group or (C-C)cycloalkyl substituted by hydroxyl group, halogen group or methoxy group, when B is N, Rand Rcan together form a 5- or 6-membered heterocycle substituted by carboxylic acid group, substituted by a halogen atom, hydroxyl group, methoxy group or hydroxymethyl group, or pharmaceutically acceptable salt. Also provided are new compounds relating to this use.

Purine derivative compounds for medical use

Growing community of inventors

Riverside, IL, United States of America

Deborah J Nelson