Merck Sharp + Dohme Corp.

Deborah Anne Nicoll-Griffith

Michael D Miller

Daria Hazuda

Jay A Grobler

The present invention is directed to methods for inhibition of HIV reverse transcriptase, treatment of infection by HIV, prophylaxis of infection by HIV, and the treatment, prophylaxis and/or delay in the onset or progression of AIDS or ARC by administering a compound of structural Formula I or a pharmaceutically acceptable salt or co-crystal thereof, wherein X is —F or —Cl, less frequently than once daily.

Methods for treatment and prophylaxis of HIV and AIDS

The present invention is directed to methods for inhibition of HIV reverse transcriptase, treatment of infection by HIV, prophylaxis of infection by HIV, and the treatment, prophylaxis and/or delay in the onset or progression of AIDS or ARC by administering a compound of structural Formula I or a pharmaceutically acceptable salt or co-crystal thereof, wherein X is &#x2014;F or &#x2014;Cl, less frequently than once daily.

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St-Basile-le-Grand, Canada

Deborah Anne Nicoll-Griffith