Syntex (u.s.a.) Inc.

Other

Deborah A Eppstein

Philip L Felgner

Thomas Gadek

Gordon H Jones

Richard B Roman

Thomas R Matthews

Elizabeth B Fraser-Smith

John J Nestor, Jr

Teresa H Ho

Barbara P Barna

Brian B Schryver

Sharad D Deodhar

N-&lsqb;1, (1-1) -dialkyloxy&rsqb; - and N- &lsqb;1, (1-1) -dialkenyloxy&rsqb;- alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor

Compounds having immunomodulatory activity comprising the optionally modified dodecapeptide fragment A-(SEQ ID No: 1)-B corresponding to residues 174 to 185 of C-reactive protein (CRP), pharmaceutical compositions thereof, and methods of treating cancer with the compositions. Liposomal formulations containing the CRP-peptide fragment are particularly efficacious when administered in conjunction with interleukin-2.

C-reactive protein fragment with immunomodulatory activity

This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R.sup.1 and R.sup.2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R.sup.3, R.sup.4, R.sup.5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, aralkyl of 7 to 11 carbon atoms, or when two or three of R.sup.3, R.sup.4, and R.sup.5 are taken together to form quinuclidino, piperidino, pyrrolidino, or morpholino; n is 1 to 8; and X is a pharmaceutically acceptable anion.

N-[.omega., (.omega.-1)-dialkyloxy]- and N-[.omega.,

This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R.sup.1 and R.sup.2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R.sup.3, R.sup.4 and R.sup.5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, aralkyl of 7 to 11 carbon atoms, or when two or three of R.sup.3, R.sup.4, and R.sup.5 are taken together to form quinuclidino, piperidino, pyrrolidino, or morpholino; n is 1 to 8; and X is a pharmaceutically acceptable anion.

N-(1,(1-1)-dialkyloxy)-and N-(1,(1-1)-dialkenyloxy

This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R.sup.1 and R.sup.2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R.sup.3, R.sup.4 and R.sup.5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, aralkyl of 7 to 11 carbon atoms, or when two or three of R.sup.3, R.sup.4, and R.sup.5 are taken together to form quinuclidino, piperidino, pyrrolidino, or morpholino, n is 1 to 8; and X is a pharmaceutically acceptable anion.

N-[1, (1-1)-dialkyloxy]-and N-[1,

This invention relates to compounds of the formula or an optical isomer thereof wherein R.sup.1 and R.sup.2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R.sup.3, R.sup.4 and R.sup.5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, aralkyl of 7 to 11 carbon atoms, or when two or three of R.sup.3, R.sup.4, and R.sup.5 are taken together to form quinuclidino, piperidino, pyrrolidino, or morpholino; n is 1 to 8; and X is a pharmaceutically acceptable anion.

N-[.omega.,(.omega.-1)-dialkyloxy]- and

N-(.omega., (.omega.-1)-dialkyloxy)- and N-(.omega.,

N-.omega.,(.omega.-1)-dialkyloxy)- and

An active agent delivery system for the controlled administration of macromolecular polypeptides which comprises a micro-suspension of water-soluble components in a polylactide matrix.

Controlled release of macromolecular polypeptides

N-(.omega.,(.omega.-1)-dialkyloxy)- and

N[.omega.,(.omega.-1)-dialkyloxy]- and

Combinations of 9-(1,3-dihydroxy-2-propoxymethyl) guanine or a pharmaceutically acceptable salt thereof, with .beta.-interferon show a surprisingly high degree of synergism in their activity against viral infections.

Synergistic antiviral composition

Co-administration of a muramyldipeptide derivative with liposomes enhances the anti-infective activity of the muramyldipeptide derivative.

Method for enhancing the anti-infective activity of muramyldipeptide

Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides.

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Menlo Park, CA, United States of America

Deborah A Eppstein