Abbott Laboratories Corporation

Deborah A Davis

Ashok V Bhatia

Madhup K Dhaon

Steven A Chamberlin

Keith A Drengler

Russell C Klix

Grant L Esser

Owen J Goodmonson

Process for the preparation of Midazolam

The present invention relates to a process of making 2-amino-1,3-propanediol by reacting 1,3-dihyrdroxyacetone dimer with an amine compound.

Process for production of 2-amino-1,3-propanediol

A process of producing atracurium besylate that substantially reduces the level of impurities in the final product and avoids the repeated use of ether is provided. In accordance with such a process, N, N'-4,10-dioxa-3,11-dioxotridecylene-1,13-bis-tetrahydropapaverine (Compound 1), methyl benzenesulfonate and a catalytic amount of an insoluble base in a solvent are combined to form a reaction mixture that is maintained for a period of time sufficient for atracurium besylate formation. The reaction mixture is then filtered to remove the insoluble base and the atracuriurn besylate is precipitated.

Process for the preparation and isolation of atracurium besylate

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Waukegan, IL, United States of America

Deborah A Davis