Novartis Ag

Advinus Therapeutics Private Limited

Other

Takeda Pharmaceutical Company Limited

Impetis Biosciences Limited

Debnath Bhuniya

Suresh Eknath Kurhade

Sandeep Bhausaheb Bhosale

Videsh Salunkhe

P Venkata Palle

Mark G Bock

Gregory Raymond Bebernitz

Dumbala Srinivas Reddy

Vinod Vyavahare

Lili Feng

Jessica Liang

Kasim A Mookhtiar

Nadim S Shaikh

Atul Kashinath Hajare

Keshav Naik

Summon Koul

Santosh Kurhade

Venkata Poornapragnacharyulu Palle

Bheemashankar A Kulkarni

Bhavesh Dave

Anil M Deshpande

Yogesh Munot

Sachin Kandalkar

Balasaheb Kobal

Gobind Sing Kapkoti

Siddhartha De

Laxmikant Datrange

Mahesh Thakkar

Sujay Basu

Umesh Singh

Kasim Mookhtiar

Mayur Mukim

Ravikumar Velayutham

Rahul Kaduskar

Tanaji Mengawade

Anita Chugh

S Gobind Kapkoti

Gagan Kukrejka

S Jayakumar Warrier

Shailesh Shinde

N Jagadeesh Mavinahalli

Rajendra Kharul

A Kasim Mookhtiar

Atul Hazare

Manoj Joshi

Nadim Shaikh

Satish Patil

Amit Bhalerao

Sandeep Bhosale

Anil Deshpande

Gobind S Kapkoti

Siddartha De

This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.

Glycoside derivatives and uses thereof

Fused bicyclic compounds are inhibitors of GPR91. The compounds, their stereoisomers, tautomers, prodrugs, polymorphs, solvates, pharmaceutically acceptable salts, and pharmaceutical compositions containing them are useful in the treatment, prevention, prophylaxis, management, or adjunct treatment of all medical conditions related to inhibition of GPR91.

Fused bicyclic compounds, compositions and applications thereof

The present disclosure relates to substituted amide compounds that are inhibitors of Fatty Acid Amide Hydrolase (FAAH), their stereoisomers, tautomers, prodrugs, polymorphs, solvates, pharmaceutically acceptable salts, and pharmaceutical compositions containing them. These compounds are useful in the treatment, prevention, prophylaxis, management, or adjunct treatment of all medical conditions related to inhibition of Fatty Acid Amide Hydrolase (FAAH), such as pain including acute and post operative pain, chronic pain, cancer pain, cancer chemotherapy induced pain, neuropathic pain, nociceptive pain, inflammatory pain, back pain, pain due to disease of various origin such as: diabetic neuropathy, neurotropic viral disease including human immunodeficient virus (HIV), herpes zoster such as post herpetic neuralgia; polyneuropathy, neurotoxicity, mechanical nerve injury, carpal tunnel syndrome, immunologic mechanisms like multiple sclerosis; sleep disorders, anxiety and depression disorders, inflammatory disorders, weight and eating disorders, Parkinson's disease, addiction, spasticity, hypertension or other disorders. The disclosure also relates to the process of preparation of the amide compounds.  The present disclosure also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.

Amide compounds, compositions and applications thereof

The present invention provides a heterocyclic compound having a TLR7, TLR9, TLR7/8, TLR7/9 or TLR7/8/9 inhibitory action, which is useful as an agent for the prophylaxis or treatment of autoimmune diseases, inflammatory diseases and the like, in particular, systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, psoriasis, inflammatory bowel disease and the like. The present invention is a compound represented by the formula (1): wherein each symbol is as described in the specification, or a salt thereof. 

Pyrrolo[3,2-c]pyridine derivatives as TLR inhibitors

The present disclosure relates to a series of spirocyclic compounds of formula (I), their stereoisomers, tautomers, prodrugs, pharmaceutically acceptable salts, polymorphs, solvates, hydrates, N-Oxides, Co crystals and formulations thereof. The disclosure also relates to process of preparation of these spirocyclic compounds.  These compounds are useful in the treatment, prevention, prophylaxis, management, or adjunct treatment of all medical conditions related to inhibition of acyl CoA diacyl glycerol acyltransferase 1 (DGAT1).

Spirocyclic compounds, compositions and medicinal applications thereof

Acetamide derivatives, their stereoisomers, tautomers, prodrugs, pharmaceutically acceptable salts, polymorphs, solvates and formulations thereof for the prophylaxis, management, treatment, control of progression, or adjunct treatment of diseases and/or medical conditions where the activation of glucokinase would be beneficial, are disclosed.  The disclosure also provides process of preparation of these acetamide derivatives.

Acetamide derivatives as glucokinase activators, their process and medicinal applications

The present disclosure provides hetero-bicyclic compounds of formula (I), their tautomers, polymorphs, stereoisomers, prodrugs, solvates, hydrates, N-oxides, co-crystals, pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by Bruton's tyrosine kinase (Btk) activity, The disclosure also relates to the process of preparation of compounds of Formula (I).  These compounds are useful in the treatment, prevention, prophylaxis, management, or adjunct treatment of all medical conditions related to inhibition of Bruton's tyrosine kinase (Btk), such as inflammatory and/or autoimmune disorder, cell proliferation, rheumatoid arthritis, psoriasis, psoriatic arthritis, transplant rejection, graft-versus-host disease, multiple sclerosis, inflammatory bowel disease, allergic diseases, asthma, type 1 diabetes, myasthenia gravis, hematopoetic disfunction, B-cell malignancies, systemic lupus, erythematosus or other disorders.

Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof

Compounds of the present disclosure are 2,2,2-tri-substituted acetamide derivatives of formula (I), its polymorphs, stereoisomers, prodrugs, solvates, pharmaceutically acceptable salts and formulations thereof, useful as Glucokinase activator. 

2,2,2-tri-substituted acetamide derivatives as glucokinase activators, their process and pharmaceutical application

Acetamide derivatives as glucokinase activators, their process and medicinal application

Glycoside derivative and uses thereof

Pyrrole-2-carboxamide derivatives, their polymorphs, stereoisomers, prodrugs, solvates, pharmaceutically acceptable salts and formulations thereof, beneficial for prophylaxis, management, treatment, control of progression, or adjunct treatment of diseases and/or medical conditions where the activation of glucokinase would be beneficial, are disclosed. The disclosure also provides process of preparation of these pyrrole-2-carboxamides. 

Pyrrole-2-carboxamide derivatives as glucokinase activators, their process and pharmaceutical application

Growing community of inventors

Howrah, India

Debnath Bhuniya