Cedars-sinai Medical Center

Siemens Healthcare Gmbh

Other

Siemens Medical Solutions Usa, Inc.

Debiao Li

Zhaoyang Fan

Anthony Christodoulou

Jianing Pang

Yibin Xie

Zhengwei Zhou

Christopher Nguyen

Gerhard Laub

Xiaoming Bi

Rohan Dharmakumar

Jaime Shaw

Zixin Deng

Sotirios A Tsaftaris

Gadi Pelled

Dan Gazit

Yutaka Natsuaki

Zulma Gazit

Behzad Sharif

Daniel S Berman

Nan Wang

Sen Ma

Hui Han

Qi Liu

Hyun W Bae

Matthias Fenchel

Sven Zuehlsdorff

Ning Jin

Shawn Wagner

Wafa Tawackoli

Pei Han

Yuhua Chen

C Noel Bairey Merz

Qi Yang

Jose Agraz

A method for performing magnetic resonance imaging on a subject comprises obtaining undersampled imaging data, extracting one or more temporal basis functions from the imaging data, extracting one or more preliminary spatial weighting functions from the imaging data, inputting the one or more preliminary spatial weighting functions into a neural network to produce one or more final spatial weighting functions, and multiplying the one or more final spatial weighting functions by the one or more temporal basis functions to generate an image sequence. Each of the temporal basis functions corresponds to at least one time-varying dimension of the subject. Each of the preliminary spatial weighting functions corresponds to a spatially-varying dimension of the subject. Each of the final spatial weighting functions is an artifact-free estimation of the one of the one or more preliminary spatial weighting functions.

Systems and methods of deep learning for large-scale dynamic magnetic resonance image reconstruction

A method of analyzing a multidimensional image tensor containing a plurality of images comprises: performing imaging scans of a subject imaging data; generating the multidimensional image tensor from the imaging data; determining a spatial basis tensor containing basis images based on the multidimensional image tensor; determining a temporal basis tensor containing basis functions for a temporal dimension based on the multidimensional image tensor; determining a core tensor that relates the spatial basis tensor to the temporal basis tensor; pre-multiplying the core tensor and the temporal basis tensor to produce a modified temporal basis tensor; storing the spatial basis tensor and the modified temporal basis tensor; and generating an image by multiplying at least (i) at least a portion of the spatial basis tensor and (ii) at least a portion of the modified temporal basis tensor.

Storage, display, and analysis of factored multidimensional images

There are provided methods for diagnosing coronary heart disease in a subject in need thereof comprising administering an admixture comprising COto a subject to reach a predetermined PaCOin the subject to induce hyperemia, monitoring vascular reactivity in the subject and diagnosing the presence or absence of coronary heart disease in the subject, wherein decreased vascular reactivity in the subject compared to a control subject is indicative of coronary heart disease. There are also provided methods for increasing sensitivity and specificity of BOLD MRI.

Assessment of coronary heart disease with carbon dioxide

A method for performing real-time magnetic resonance (MR) imaging on a subject is disclosed. A prep pulse sequence is applied to the subject to obtain a high-quality special subspace, and a direct linear mapping from k-space training data to subspace coordinates. A live pulse sequence is then applied to the subject. During the live pulse sequence, real-time images are constructed using a fast matrix multiplication procedure on a single instance of the k-space training readout (e.g., a single k-space line or trajectory), which can be acquired at a high temporal rate.

Systems and methods of on-the-fly generation of 3D dynamic images using a pre-learned spatial subspace

A method of performing multidimensional magnetic resonance imaging on a subject comprises collecting imaging data for a region of interest of the subject, the imaging data related to one or more spatially-varying parameters of the subject within the region of interest; collecting auxiliary data for the region of interest in the subject, the auxiliary data related to one or more time-varying parameters of the subject within the region of interest; linking the imaging data and the auxiliary data; and constructing an image tensor with one or more temporal dimensions based on at least a portion of the linked imaging data and at least a portion of the linked auxiliary data.

Low-rank tensor imaging for quantitative MRI

In various embodiments, the invention teaches systems and methods for magnetic resonance imaging. In some embodiments, the invention teaches systems and methods for determining the source of pain in intervertebral discs by measuring one or more physiological biomarkers associated with disc pain and/or disc degeneration.

Non-invasive pH-dependent imaging using quantitative chemical exchange saturation transfer (qCEST)

The invention provides methods for diagnosing coronary heart disease in a subject in need thereof comprising administering an admixture comprising CO2 to a subject to reach a predetermined PaCO2 in the subject to induce hyperemia, monitoring vascular reactivity in the subject and diagnosing the presence or absence of coronary heart disease in the subject, wherein decreased vascular reactivity in the subject compared to a control subject is indicative of coronary heart disease. The invention also provides methods for increasing sensitivity and specificity of BOLD MRI.

A coil assembly for MR imaging includes an RF coil element and a shim coil array with a shim coil element. The shim coil element is physically separated from the RF coil element. The shim coil element includes a DC current loop having a DC power supply connection to allow DC current to generate a local B0 magnetic field. The coil assembly simultaneously provides an RF mode for at least one of transmit or receive and a direct current mode to generate a local B0 magnetic field for at least one of B0 shimming an imaging space, MRI spatial encoding of tissue spins, or MRI temporal encoding of tissue spins. The mutual inductance between the shim coil element and the RF coil element is minimized by configuration of blocking elements in the shim coil in order to minimize the RF interaction there between.

Magnetic resonance coils for simultaneous imaging and B0 shimming

A unified coil assembly for magnetic resonance imaging is disclosed. The coil assembly includes an RF coil element and a shim coil array with a shim coil element. The shim coil element is physically separated or partially separated from the RF coil element. The shim coil element includes a DC current loop having a DC power supply connection to allow DC current to generate a local BO magnetic field. The unified coil array assembly is configured to simultaneously provide an RF mode for at least one of transmit or receive and a direct current mode to generate a local B0 magnetic field for B0 shimming Larger number of shim coils relative to the RF coil element provides superior shimming performance. The mutual inductance between the shim coil element and the RF coil element is minimized by proposed geometrical decoupling methods in order to minimize the RF interaction between the two.

Unified coil (UNIC) systems and method for next generation magnetic resonance coils

In various embodiments, the present invention teaches methods and related systems for imaging the coronary arteries in high spatiotemporal resolution for the assessment of coronary stenosis. In some embodiments, the method teaches the use of a 3D radial k-space trajectory, continuous acquisition, retrospective cardiac and respiratory self-gating, and non-rigid cardiac and respiratory motion correction to reconstruct any arbitrary cardiac phase with minimal motion artifacts and high image quality.

Method and system for cardiac motion corrected MR exam using deformable registration

Magnetic resonance imaging utilizing a continuous spoiled gradient echo sequence with 3D radial trajectory and 1D self-gating for respiratory motion detection can be used to characterize respirator motion in the abdomen. The resulting image data is acquired and is retrospectively sorted into different respiratory phases based on their temporal locations within a respiratory cycle, and each phase is reconstructed via a self-calibrating conjugate gradient sensitivity encoding (CG-SENSE) program.

Characterization of respiratory motion in the abdomen using a 4D MRI technique with 3D radial sampling and respiratory self-gating

A method of determining an exchange rate between a solute material and a solvent material in chemical exchange with each other in a sample comprises performing a plurality of CEST scans on the sample to determine a reference data signal and a label data signal; simulating a plurality of CEST scans on the sample to obtain a reference dictionary signal and a plurality of label dictionary signals, each label dictionary signal corresponding to a candidate exchange rate; correcting the reference dictionary signal and each label dictionary signal for a magnetization transfer effect; determining a final data signal based on the reference data signal and the label data signal; determining a plurality of final dictionary signals based on the reference dictionary signal and the plurality of label dictionary signals; and determining the exchange rate by matching the final data signal to one of the plurality of final dictionary signals.

Methods and systems for chemical exchange saturation transfer signal matching

In some embodiments, the present application discloses systems and methods for cardiac MRI that allow for continuous un-interrupted acquisition without any ECG/cardiac gating or synchronization that achieves the required image contrast for imaging perfusion defects. The invention also teaches an accelerated image reconstruction technique that is tailored to the data acquisition scheme and minimizes or eliminates dark-rim image artifacts. The invention further enables concurrent imaging of perfusion and myocardial wall motion (cardiac function), which can eliminate the need for separate assessment of cardiac function (hence shortening exam time), and/or provide complementary diagnostic information in CAD patients.

Growing community of inventors

South Pasadena, CA, United States of America

Debiao Li