Lupin Laboratories Limited

Debashish Datta

Bishwa Prakash Rai

Vinod George

Kishor Mehre

This invention relates to reactive derivatives of 2-(2-aminothiazol-4-yl)-2-methoxyimino acetic acid and 1H-tetrazol-1-acetic acid of the following general formula I, ##STR1## wherein ##STR2## as well as to use thereof in the manufacture of cephalosporin antibiotics such as cefotaxime, ceftriaxone and cefazolin.

Method for manufacture of cephalosporin and intermediates thereof

This invention relates to reactive derivative of 2-(2-amino-4-thiazolyl)-(Z)-2-�(1-tert butoxycarbonyl-l-methylethoxy) imino!acetic acid of the following formula I ##STR1## as well as to the use thereof in the manufacture of cephalosporin antibiotic such as ceftazidime of formula II. ##STR2##

Process for manufacture of cephalosporin such as ceftazidime and

This invention relates to reactive derivatives of 2-(2-aminothiazol-4-yl)-2-methoxyimino acetic acid and 1H-tetrazol-1-acetic acid of the following general formula I, ##STR1## wherein R.sub.3 = ##STR2## as well as to use thereof in the manufacture of cephalosporin antibiotics such as cefotaxime, ceftriaxone and cefazolin.

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Mandideep, India

Debashish Datta