Council of Scientific and Industrial Research

Debabrata Chanda

Ajit Kumar Saxena

Dilip Manikrao Mondhe

Arvind Singh Negi

Ayyampudur Palanisamy Prakasham

Suaib Luqman

Tandeep Kaur

Atul Gupta

Arjun Singh

Aastha Singh

Kaneez Fatima

The present invention relates to benzylidene indanones of general formula 1. The compounds exhibited tubulin polymerisation inhibition. A series of compounds 2-benzylidene 3-(3,4,5-trimethoxyphenyl) indanones having general formula 1 were synthesized from gallic acid through a chemical process. 2-(3,4-Methylenedioxybenzylidine), 3-(3,4,5-trimethoxyphenyl), 4,5,6-trimethoxyindanone (8), a representative compound of this series possessing the molecular formula CHO, was synthesized from gallic acid and exhibits potent anticancer activity. Compound 8 was evaluated for acute oral activity in Swiss albino mice and found to be safe up to 300 mg/kg body weight. The anticancer activity of the compounds has been determined, in order to obtain new potent and cost effective molecules using an in vitro cytotoxicity assay. 

Benzylidene indanones and processes for preparation and use thereof

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Lucknow, India

Debabrata Chanda