University of Michigan

Deanna Montgomery

Jolanta Grembecka

Tomasz Cierpicki

Dmitry Borkin

Szymon Klossowski

Aaron M Bender

Henry Mosberg

Jing Deng

Hao Li

Sean Henry

Anthony Nastase

Aubrie Harland

David Rogawski

Zhuang Jin

Marta Krotoska

Marta Szewczyk

Jin Zhuang

Provided herein are small molecule inhibitors of ASH1L activity and small molecules that facilitate ASH1L degradation and methods of use thereof for the treatment of disease, including acute leukemia, solid cancers and other diseases dependent on activity of ASH1L.

ASH1L inhibitors and methods of treatment therewith

Disclosed herein are compounds useful for modulating the mu-opioid receptor ('MOR') and/or delta-opioid receptor ('DOR'), and methods of using these compounds to treat diseases and conditions, such as pain. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: wherein the substituents are as described.

Peptidomimetics and methods of using the same

Growing community of inventors

Ann Arbor, MI, United States of America

Deanna Montgomery