Baxter International Inc.

Baxter Travenol Laboratories, Inc.

Other

Medichem Research, Inc.

Deanna J Nelson

Ton That Hai

David Eugene Pereira

Ana Srnak

Bruce D Rowe

Lecon Woo

Michael T Flavin

Julian P Breillatt, Jr

Sumner A Barenberg

Timothy N Estep

Naomi L Weinless

Paul Soltys

Sharon Pokropinski

Richard Appl

Gary Jesmok

Julian F Borgia, Deceased

A novel group of compounds is disclosed for decorating the surface of synthetic polymeric or tissue derived prostheses to prevent adverse rejection events. The decorating molecules are obtained as derivatives of naturally occurring polysaccharides, derivatized to provide functionally reactive groups at the termini thereof, and the reacting with nucleophilic or other groups on the surface of the prosthesis in a simple one step reaction. Some of these reagents are useful in noncovalent adsorption to polyolefinic or perfluorocarbon based materials. Finally, phospholipids partially substituted with the nonantigenic polysaccharides provide a superior bipolar component for liposome formation.

Biocompatible surfaces and a method for their preparation

Novel polysaccharide compounds are disclosed for decorating biomolecular surfaces to increase isotropic size and mask antigenicity. The oligosaccharides may be synthesized as repeating disaccharide units, or may be derived by acid hydrolysis of naturally occurring polysaccharides. Such natural sources include chondroitins obtained from shark cartilage, or hyaluronic acid. The polyanionic sulfate groups contained in the sugar moieties impart negative charges which repel the molecules from the negatively charged wall of capillaries, to lengthen retention times of decorated drug molecules, such as crosslinked hemoglobin, in the peripheral circulation.

Reagents for isotropic size enhancement of a peptide, protein,

Therapeutic hemoglobin composition having isotropically increased size

An anhydrous solid water-soluble composition and method for direct controlled administration of beneficial agents to a flowing medical fluid. The beneficial agents are geometrically dispersed in a solid matrix and isolated from one and other to allow administration of mutually reactive agents.

Method and composition for administration of beneficial agent by

This invention relates to methods for treating Adult Respiratory Distress Syndrome (ARDS) which involves the administration of 2,3-alkylcarbonyloxybenzoic acid and salts thereof wherein the alkyl group has 2-18 carbon atoms.

Use of 2,3 alkylcarbonyloxybenzoic acid in treating adult respiratory

A non-immunogenic mixture of hemoglobin based modified monomers and oligomers produced by the polymerization of a hemoglobin based solution in the presence of a three membered heterocyclic ring, i.e. polyether oxirane. The modified hemoglobin composition has a P.sub.50 of at least equivalent to the P.sub.50 of human red blood cell hemoglobin.

Oxirane-modified hemoglobin based composition

A process for the production of crosslinked hemoglobin comprises crosslinking hemoglobin in the presence of sodium tripolyphosphate.

Process for the production of crosslinked hemoglobin in the presence of

Bis(salicyl) diesters useful as cross-linking agents for hemoglobin are prepared in high yield and purity by reacting salicylic acid or a derivative thereof with a lower aliphatic dicarboxylic acid halide in a lower aliphatic ketone or nitrile solvent in the presence of a pyridine derivative. The desired diester is recovered from the resulting insoluble pyridine derivative salt.

Preparation of bis(salicyl) diesters

An improved method of synthesizing 3,5-dibromosalicylic acid provides a highly purified pharmaceutical grade product free of toxic by-products and solvents. The purified product may be utilized as an intermediate in synthesizing pharmaceutical grade substances, as a bactericide when incorporated into topical ointments, and as an adjuvant in drug absorption systems.

Pharmaceutical grade 3,5-dibromosalicylic acid and metohd for

Synthetic polyesters are employed as calorie sources for parenteral or enteral nutrition. The polyesters are hydrolyzed and respired by the body and offer the advantage of high calorie density when compared to conventional or other synthetic calorie sources.

Nutrient polyesters

Synthetic monesters are employed as calorie sources for parenteral or enteral nutrition. The monoesters are hydrolyzed and respired by the body and offer the advantage of high calorie density when compared to conventional or other synthetic calorie sources.

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Libertyville, IL, United States of America

Deanna J Nelson