Sonus Pharmaceuticals, Inc.

Dean R Kessler

Steven C Quay

Panayiotis P Constantinides

Karel J Lambert

Alexander K Tustian

Nagesh Palepu

Ronald A Roy

Dilip Worah

The present invention provides methods for administering a taxane composition for the treatment of cancer. In one aspect, the compositions are not diluted prior to administration. Some embodiments provide methods for administering a taxane as a bolus injection or an intravenous infusion in less than about 30 minutes. In other aspects, the invention provides methods for administering a taxane to provide high concentrations of the taxane in blood or in tumors. Another aspect provides methods for administering a taxane to provide anti-tumor activities against solid tumors. In some embodiments, the methods provide anti-tumor activities against tumors that were resistant to conventional taxane administration methods. In some embodiments, the methods provide anti-tumor activities against colorectal tumors.

Method for treating colorectal carcinoma using a taxane/tocopherol formulation

A method of activating an ultrasound contrast agent such that an increased number of microbubbles are produced and subsequent ultrasound images using the activated agent is enhanced. Hypobaric methods are disclosed which provide significant increases in bubble population per unit volume over unactivated solutions. The method is particularly useful for the activation of the dispersed phase in a gas or liquid in liquid emulsion.

Nucleation and activation of a liquid-in-liquid emulsion for use in

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Edmonds, WA, United States of America

Dean R Kessler