Smithkline Beckman Corporation

Smithkline Beecham Corporation

Dean P Taylor

Martin M Rosenberg

James E Strickler

James A Fornwald

Thomas R Berka

Joselina G Gorniak

Louis R Fare

Jenifer B Widger

Yong K Oh

This invention relates to a process for producing a heterologous polypeptide in Streptomyces which involves transforming a Streptomyces organism with a recombinant DNA molecule comprising an LEP-10 of LTl sequence selected from the group consisting of a sequence encoding a gene expression unit, a promoter sequence or an export control encoding sequence each operatively linked to a heterologous coding sequence and then culturing the transformed Streptomyces such that the heterologous polypeptide is expressed.

Protein protease inhibitors from streptomyces

This invention relates to novel protein protease inhibitors as well as DNAs encoding same and vectors and transformed host cells useful for the recombinant production of the inhibitors.

A plasmid naturally present in N. orientalis can be used as a vector for cloning or expression in Actinomycetales and to derive other vectors.

Plasmids from nocardia

Small cosmid cloning vectors having two antibiotic resistance markers, selected from chloramphemicol resistance, streptomycin and spectinomycin resistance and tetracycline resistance markers, at least one having a unique restriction site.

Growing community of inventors

King of Prussia, PA, United States of America

Dean P Taylor