Emory University

Nutriquest, LLC

The United States Government As Represented by the Department of Veterans Affairs

Kyowa Hakko Bio Co., Ltd.

Inmune Bio Inc

Dean P Jones

Satoru Furukawa

Thomas R Ziegler

Samuel C Dudley, Jr

Kenjiro Shimada

Christopher J Barnum

Douglas I Walker

Quinlyn A Soltow

Raymond J Tesi

Maria Elizabeth De Souza Rodrigues

Maria De Lourdes Gamez Tansey

Thomas Ziegler

The disclosure concerns a method of treating complications of acute or chronic hyperglycemia and/or diet-induced obesity comprising: (i) determining whether a patient suffers from complications related to acute or chronic hyperglycemia and/or diet induced obesity, and if so, (ii) administering to the patient in need thereof a selective inhibitor of soluble TNF-&#x3b1; but not transmembrane TNF-&#x3b1;. For purposes herein, complications of acute or chronic hyperglycemia and/or diet-induced obesity include: diabetes mellitus, insulin resistance, hepatic steatosis, non-alcoholic hepatic steatosis, fibrotic liver disease, vascular disease, and chronic intestinal inflammation.

Method for treating complications related to acute or chronic hyperglycemia

Described herein are computer-readable storage mediums, methods and systems useful for analyzing samples via mass spectrometry. Aspects described herein include methods for normalizing mass spectrometry data that include providing a reference set of mass spectrometry data obtained from a first external standard sample having one or more isotopic standards, wherein the reference set of mass spectrometry data comprises one or more m/z intensity ratios. Methods described herein are useful for reducing errors based on instrument response and ionization efficiencies and improve reproducibility of data from instrument to instrument and from day to day.

Computer readable storage mediums, methods and systems for normalizing chemical profiles in biological or medical samples detected by mass spectrometry

A composition and a method effective in preventing or treating stomatitis are presented. The composition contains glutathione or a pharmaceutically acceptable salt thereof and/or orotic acid or a derivative thereof or a pharmaceutically acceptable salt thereof is provided.

Composition and method for treatment of stomatitis

A method for predicting onset or risk of atrial fibrillation in a subject includes determining the presence of an oxidative stress marker, such as glutathione, cysteine, and/or a derivative of a reactive oxidative metabolite (DROM).

Method for predicting onset/risk of atrial fibrillation (AF)

The present disclosure describes methods for minimizing oxidative damage in an animal or human during or after malnutrition, underfeeding or fasting, especially during refeeding after undernutrition or malnutrition, and for minimizing oxidant damage during or after toxicity resulting from chemotherapy, alcoholism, irradiation therapy or chemical or environmental exposure to a toxic compound. Administration of an effective amount of a gut trophic growth factor (GTGF) effective for improving gut and/or systemic antioxidant status results in improved clinical condition and/or outcome for the patient or animal to which the GTGF has been administered. In the context of the present disclosure, GTGF includes fibroblast growth factors, keratinocyte growth factor, hepatocyte growth factor, insulin-like growth factor I, glucagon, glicentin, and glucagon-like peptide.

Use of gut-trophic growth factors to improve oxidative status

The present disclosure provides methods for minimizing oxidative damage in an animal or human during or after malnutrition, underfeeding or fasting, especially during refeeding after undernutrition or malnutrition, and for minimizing oxidant damage during or after toxicity resulting from chemotherapy, alcoholism, irradiation therapy or chemical or environmental exposure. The present methods comprise the step of administering an amount of keratinocyte growth factor effective for improving gut and/or systemic antioxidant status.

Use of keratinocyte growth factor to improve oxidative status

Administration of one or more of glutathione, its disulfide dimer, ascorbate-2-phosphate, or N-acetyl-L-cysteine, with or without antioxidants, is suitable for the treatment of influenza virus infection, as well as prophylactic prevention of influenza virus infection.

Growing community of inventors

Decatur, GA, United States of America

Dean P Jones