Pacesetter, Inc.

Neuropace, Inc.

Incube Labs, LLC

Dean P Andersen

Mir A Imran

Dorin Panescu

Jong Gill

Ion E Opris

Stephen T Archer

John Dunagan Pearson

Eiji Shirai

Marc Ryat

Benjamin T Persson

William Douglas Barrett

Jin-Woo Park

Vikram Malhotra

George Andrew Mangogna

Cem M Shaquer

Eric Christophe Labbe

Gavin L Rade

Philip M FitzSimons

David Doudna

Philip Matthew Fitzsimons

Christopher Gloschat

Thomas Ng

Shuo Li

Embodiments described herein relate to an implantable device that include an inductor coil, a storage capacitor, active circuitry, and a sensor, but doesn't include an electrochemical cell, and methods for use therewith. During first periods of time, the storage capacitor accumulates and stores energy received via the inductor coil from a non-implanted device. During second periods of time, interleaved with the first periods of time, and during which energy is not received from the non-implanted device, the active circuitry of the implantable device is powered by the energy stored on the storage capacitor and is used to perform at least one of a plurality of predetermined operations of the implantable device, including, e.g., obtaining a sensor measurement from the sensor of the implantable device, transmitting a communication signal including a sensor measurement to the non-implanted device, and/or receiving a communication signal from the non-implanted device.

Method and apparatus for a burst operation pressure sensor

A system is provided that includes electrodes configured to be implanted in a body, and a pulse generator (PG) circuitry to deliver a stimulus to one or more of the electrodes. The system also includes sensing circuitry configured to define a sensing channel between one or more of the electrodes to sense signals indicative of a physiologic activity of interest, and the sensing circuitry further configured to collect a calibration signal over the sensing channel. The sensing circuitry and PG circuitry are housed within an implantable medical device (IMD). The system also includes one or more processors configured to determine a signal characteristic of interest (COI) of the calibration signal. The one or more processors are also configured to compare a signal COI of the stimulus to the signal COI of the calibration signal, and adjust a parameter of the sensing circuitry or PG circuitry based on the comparison.

Method and system for calibrating sensing circuitry of an implanted medical device

A system is provided that includes one or more electrodes configured to be implanted proximate to a sensing site, and a memory configured to store first and second sets of filter parameters that define first and second noise stop bands. The system also includes an implantable medical device (IMD) that has inputs configured to receive sensed signals, the sensed signals include frequency components associated with physiology activity and frequency components associated with noise. The IMD also includes a band-stop filter communicating with the sensing channel inputs. When executing program instructions, a processor switches the band-stop filter from the first set of filter parameters to the second set of filter parameters to shift from the first noise stop band to the second noise stop band based on the noise in the environment of the patient.

Method and system for filtering noise of an implantable medical device

Techniques for calibrating a low frequency (LF) clock of an IMD are disclosed, wherein the IMD also includes a high frequency (HF) clock. This includes determining an average, or a surrogate thereof, of how many HF clock cycles of a HF clock signal (produced by the HF clock) occur per LF clock cycle of a predetermined number N of LF clock cycles of the LF clock signal (produced by the LF clock), wherein N is an integer that is at least 2. This also includes comparing the average or a surrogate thereof to a corresponding target value that the average or the surrogate thereof would be equal to if the frequency of the LF clock signal equaled a target frequency for the LF clock, wherein the corresponding target value need not be an integer. The LF clock is calibrated by adjusting the frequency thereof based on results of the comparing.

Implantable medical devices including low frequency and high frequency clocks and related methods

An implantable medical device (IMD) and method are provided. The IMD includes a sensing channel configured to obtain biological signals indicative of biological behavior of an anatomy of interest over a period of time. The biological behavior has a feature of interest that repeats over time. The biological signals have clinically relevant (CR) segments that include information related to the feature of interest. The biological signals have non-clinically relevant (NCR) segments that do not include information related to the feature of interest. At least one of circuitry or a processor are configured to compare the biological signals to an amplitude window to distinguish the CR segments from the NCR segments, save to memory the CR segments and delete the NCR segments, save to memory time information indicative of a duration of the NCR segments that were deleted and to form a lossy compressed data set for the biological signals.

Method and device for managing biological activity data storage utilizing lossy compression

A system for monitoring blood pressure includes an implantable medical device (IMD) and an external device (ED). The IMD senses an electrogram (EGM) signal, identifies a feature thereof indicative of a ventricular depolarization, and transmits a conductive communication signal through patient tissue indicating when the ventricular depolarization occurred. The ED is worn against skin and configured to receive the conductive communication signal. The ED is also configured to sense a plethysmography (PG) signal and identify a feature thereof indicative of when a pulse wave responsive to the ventricular depolarization reaches a region of the patient adjacent the ED, and determine a delay time (TD) indicative of how long it takes the pulse wave to travel from the patient's heart to the region of the patient adjacent to the ED. The TD is a surrogate of the patient's blood pressure and useful for monitoring the patient's blood pressure and/or changes therein.

Methods, systems and devices that use conductive communication to determine time delay for use in monitoring blood pressure

Devices and methods for dynamically controlling sensitivity associated with detecting R-waves while maintaining the fixed detection threshold are described herein. One such method includes sensing an analog signal indicative of cardiac electrical activity, converting the analog signal indicative of cardiac electrical activity to a digital signal indicative of cardiac electrical activity, and detecting R-waves by comparing the digital signal indicative of cardiac electrical activity to a fixed detection threshold to thereby detect threshold crossings that corresponds to R-waves. The method further includes selectively adjusting a gain applied to the digital signal indicative of cardiac electrical activity to thereby selectively adjust a sensitivity associated with the detecting R-waves, while maintaining the fixed detection threshold.

Dynamic control of sensitivity associated with detecting R-waves

Certain embodiments of the present technology relate to temperature sensors for using in an implantable medical device, and methods for use therewith. Such a method can include alternating between producing a first base-to-emitter voltage drop (VBE1) and a second base-to-emitter voltage drop (VBE2), and alternating between using a capacitor to store the VBE1, which is complimentary to absolute temperature (CTAT), and using the same capacitor to store a &#x394;VBE=VBE2&#x2212;VBE1, which is proportion to absolute temperature (PTAT). The method also includes using a sigma-delta modulator that includes the capacitor to produce a signal having a duty cycle (dc) indicative of the &#x394;VBE stored using the capacitor, and producing a temperature measurement based on the signal having the duty cycle (dc) indicative of the &#x394;VBE.

Highly accurate temperature sensors, and calibrations thereof, for use with implantable medical devices

The methods and systems herein generally relate to generating stimulation waveforms for a therapy of a neurostimulation (NS) device in a patient. The methods and systems receive a target stimulation waveform from a user interface, calculate a timing resolution of the target stimulation waveform, determine target amplitude resolutions of the target stimulation waveform, identify whether a mathematical relationship exists between the target amplitude resolutions, and automatically designate one of a first, second, or third generator circuits based on at least one of the timing resolution, the amplitude, or the mathematical relationship. The systems and methods further transmit the target stimulation waveform and an activation instruction for the designated one of the first, second, or third generator circuits along the communication link to a NS device. The NS device includes the first, second, and third generator circuits configured to generate different first, second, and third types of stimulation waveforms.

Methods and systems for generating stimulation waveforms for a neurostimulation therapy

An implantable medical device and method are provided for comprising a sensing circuit that is configured to sense and output physiologic data indicative of a physiologic characteristic of a patient and at least one processor. A memory is coupled to the at least one processor. The memory stores program instructions and processed data. The program instructions are executable by the at least one processor to execute general operational functions within the IMD. A hybrid signal processing (HSP) circuit is coupled to the at least one processor and the sensing circuit. The HSP circuit is adapted to filter the physiologic data. The HSP circuit comprises a plurality of first order filters, a plurality of higher order filters, and a switch matrix that is configured to interconnect a combination of the first and higher order filters to form a hybrid digital filter having a select composite frequency response that utilizes no more than a select power demand.

Hybrid signal processing circuit for implantable medical devices and methods

Circuits, devices and methods are provided to manage modifications to protected registers within an implantable medical device (IMD). The circuit comprises a bus controller that includes an address register, an unlock register and a protected register (PR) enable unit. The PR enable unit sets a protect enable signal to an access state based on content loaded into the unlock register. A peripheral block includes a protected register that retains content for operating the IMD. The peripheral block includes a register access input to receive the protected enable signal. A PR write control unit is provided to enable an attempted write of the content from a data interface to the protected register when the protected enable signal has an access state.

Method and device to manage modifications of protected registers in an implantable medical device

A flexible antenna is associated with an active implantable medical device to facilitate communication between the implantable medical device and an external component in the outside world via, for example, long range or far field telemetry. The flexibility of the antenna allows it to conform to the shape of the location at which it is situated, such as on the cranial bone of a patient for an antenna associated with a cranially implanted medical device. The conformability of the antenna helps to maintain the antenna in the desired shape and to maintain it in the desired location relative to implantable medical device and the patient and improves patient comfort.

Anatomically compliant antenna for implantable medical device

Embodiments of the invention provide an architecture, system and methods for optimizing power utilization for transdermal iontophoretic drug delivery which maintain a iontophoretic driving voltage at a reduced or even minimum value to support an iontophoretic delivery current. The reduced voltage reduces the power requirements for a transdermal iontophoretic delivery system during a period of drug delivery. Embodiments of an architecture for implementing this approach can utilize a controller which compares the desired current to the actual current and adjusts the voltage to reduce the amount of power used for iontophoretic drug delivery. The controller can comprise a state machine or microprocessor. Embodiments of the invention are particularly useful for extending the battery life of transdermal iontophoretic drug delivery systems.

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San Jose, CA, United States of America

Dean P Andersen