Protasis Corporation

Dean Olson

Tim L Peck

Jim Norcross

Jonathan V Sweedler

David M Strand

An NMR system comprises an NMR probe comprising multiple NMR detection sites. Each of the multiple NMR detection sites comprises a sample holding void and an associated NMR microcoil. The NMR system further comprises a controllable fluid router operative to direct fluid sample to the multiple NMR detection sites.

Microfluidic device with multiple microcoil NMR detectors enabling fluidic series communication

Microfluidic device with multiple microcoil NMR detectors and field gradient focusing

An NMR method of analyzing an analyte comprises feeding an analyte sample fluid to an NMR flow cell. The NMR flow cell comprises an RF microcoil operably associated with an enlarged containment region. The mobile phase of the analyte sample flowing through the NMR flow cell has a solvent gradient greater than 10% per minute. The analyte sample fluid can be fed to the NMR flow cell from an analyte extraction chamber, e.g., operative to perform liquid chromatography, capillary electrophoresis, or the like, especially a capillary-based analyte extraction chamber integrated in an NMR probe with the NMR flow cell. A sample volume is held in the NMR flow cell for equilibration less than 1 hour, preferably less than 30 minutes prior to actuating NMR analysis of the observe volume in the microcoil.

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Champaign, IL, United States of America

Dean Olson