National Yang Ming Chiao Tung University

Nanotrend Ino-Tech Inc.

Dean-Mo Liu

Meng-Hsuan Hsiao

Yi-Chieh Chen

Yun-Ru Hsieh

San-Yuan Chen

Wei-Ting Huang

Yu-Cheng Jian

Shang-Hsiu Hu

Kun-Ho Liu

Chang-Yi Lin

Yunn-Tzer Lu

Wen-Lien Wang

Shu-Han Liu

Yi-Ling Wang

Pei-Ling Liu

Yi-Hsin Chen

Yung-Hsin Chang

Yu-Cheng Chien

Yan-Hwa Wu Lee

Po-Jung Chen

Yun-Chun Huang

Ru-Tsun Mai

Chung-Yu Hsu

Hao-Syun Chou

Yi-Chi Lee

The present invention provides a virus collection matrix, including: a porous gel or fibrous structure formed by a positively charged polymer material; and a plurality of ACE 2 receptors. The plurality of ACE 2 receptors are negatively charged, and distributed and covered on the surface of the porous gel or fibrous structure. The whole virus collection matrix is positively charged.

Virus collection matrix

An amphiphilic polymer, an amphiphilic polymer manufacturing method, a contact lens material including the amphiphilic polymer, and contact lens manufacturing method are provided. The amphiphilic polymer includes poly(dimethylsiloxane) and amphiphilic chitosan bonded to the same. The contact lens material includes the amphiphilic polymer. The amphiphilic polymer manufacturing method includes providing a poly(dimethylsiloxane), providing an amphiphilic chitosan, and bonding the amphiphilic chitosan to the poly(dimethylsiloxane).

Amphiphilic polymer, amphiphilic polymer manufacturing method, contact lens material including the amphiphilic polymer, and contact lens manufacturing method

Disclosed herein is a ganetespib-containing particle, which includes an active ingredient selected from ganetespib, a pharmaceutically acceptable salt of ganetespib, and a combination thereof, and an amphiphilic chitosan-based carrier carrying the active ingredient. Also disclosed herein are a pharmaceutical composition including the ganetespib-containing particle, and use of such pharmaceutical composition in treating cancer.

Ganetespib-containing particle, pharmaceutical composition comprising the same, and their use in anticancer treatment

An amphiphilic polymer, an amphiphilic polymer manufacturing method, use of an amphiphilic polymer as a contact lens material, and a contact lens material including the same are provided. The amphiphilic polymer includes amino-conjugated mono-HEMA (mHEMA-NH) and amphiphilic chitosan bonded to the same. The amphiphilic polymer manufacturing method includes providing a mHEMA-NH, providing an amphiphilic chitosan, and bonding the mHEMA-NHto the amphiphilic chitosan.

Amphiphilic polymer and manufacturing method thereof, use of amphiphilic polymer as contact lens material, contact lens material including amphiphilic polymer

A manufacturing method of amphiphilic macromolecules is provided. The method includes: reacting the first acrylic acid with N,N'-carbonyldiimidazole to obtain a modified acrylic acid derivative; and reacting the modified acrylic acid derivative with the siloxane derivative to obtain amphiphilic macromolecules. Wherein, the terminal of the first acrylic acid has a hydroxyl group. Wherein, the siloxane derivative is a hydroxyl-terminated, acrylamide-terminated, epoxy-terminated or amine-terminated polysiloxane molecule.

Amphiphilic macromolecules, contact lens thereof and preparing methods thereof

The present disclosure herein provides a compound prescription colloidal eyedrop gel. The compound prescription colloidal eyedrop gel includes a plurality of carboxymethyl-hexanoyl chitosan (CHC) micelles, a basic structural stabilizer connecting the plurality of CHC micelles, a first drug inside the CHC micelle, and a second drug outside the CHC micelle.

Compound prescription colloidal eyedrop gel and methods of making the same

A nano-photoacoustic imaging agent is disclosed. The nano-photoacoustic imaging agent includes a porous carrier and a gold filling material embedded in the porous carrier. A method for the preparation of the nano-photoacoustic imaging agent is also provided.

Nano-seaurchin contrast agents with pore-filled gold nanorods and the preparation method thereof

The present invention discloses a dissoluble PDMS-modified p(HEMA-MAA) amphiphilic copolymer and the method of fabricating the same. The amphiphilic copolymer of the present invention is fabricated via chemically bonding HEMA, MAA, and poly(dimethylsiloxane), bis(3-aminopropyl) terminated (PDMS) in aqueous solution. The PDMS-modified p(HEMA-MAA) amphiphilic copolymer can be dissolved completely in polar solvents, particularly alcohol solvents, to facilitate subsequent processing. The amphiphilic copolymer features adjustable hydrophobic-hydrophilic properties and exhibits excellent biocompatibility. Thus, it can be utilized in a number of advanced applications, including anti-fouling and drug delivery.

Dissoluble PDMS-modified p(HEMA-MAA) amphiphilic copolymer and method for fabricating the same

The present invention discloses a drug-carrying contact lens and a method for fabricating the same. The drug-carrying contact lens comprises a contact lens containing at least one amphiphatic hybrid nanocarrier carrying drug molecules. According to the heat or light sensitivity of the drug molecule, the present invention respectively fabricates an encapsulation-type drug-carrying contact lens and a drug-soaking type drug-carrying contact lens. The present invention uses a highly-biocompatible amphiphatic hybrid nanocarriers having superior drug encapsulation capability to wrap the drug molecules. Thereby, the drug molecules are uniformly distributed in the contact lens and can be gradually and locally released to the eye of the user wearing the contact lens. Therefore, the present invention can prevent or cure ocular diseases with the loss and side effects of the drug being reduced.

Drug-carrying contact lens and method for fabricating the same

A hollow sphere from amphiphilic chitosan derivatives and a method of preparing an amphiphilic chitosan derivative complex for medical use are disclosed, and the hollow sphere from amphiphilic chitosan derivatives comprises: chitosan derivatives represented by the following formula (I), which self-assemble and form a hollow sphere in a solvent; 

Hollow sphere from amphiphilic chitosan derivatives and method of preparing amiphiphilic chitosan derivative complex for medical use

A stable and taste masked pharmaceutical dosage form includes porous apatite grains and a drug entrapped in pores of said grains, wherein said grains have a size of 0.1-1000 &#x3bc;m and said pores of said grains have an opening of 0.5-300 nm. A process for preparing the stable and taste masked pharmaceutical dosage form is also disclosed.

Growing community of inventors

Hsinchu County, Taiwan

Dean-Mo Liu