Focal, Inc.

Other

University of Texas System

The Coca-cola Company

Genzyme Corporation

Dean M Pichon

David J Nedder

Amarpreet S Sawhney

George E Selecman

Bradley C Poff

David A Melanson

Stephen Jack Herman

J Jeffrey Kablik

Jeffrey Alan Hubbell

Luis Z Avila

Arthur J Coury

Thomas Bromander

Shikha P Barman

Stephen D Goodrich

Ronald S Rudowsky

Mark T Kieras

John C Spiridigliozzi

Donald L Elbert

Chandrashekar P Pathak

Thomas S Bromander

Marc A Levine

Douglas Ely

Joseph M Ladina

Douglas J Weaver

Michael G Dumont

John M Kirwan

Marc Alan Levine

Douglas J K Weaver

Albert H Linder

John D Knight

Thomas P Hambleton

Daniela Homza-Stark

John R Sousa

Douglas JK Weaver

A modular system is described for construction of fluid applicators for open or endoscopic surgery from modular components. Lengths of tubing of various lengths, and devices to be carried by said tubing, are pre-fitted with standard adapters to mate with each other, thereby forming cannula sections and applicator sections. Interconnectors may also be provided, particularly for provision of articulation. The tubing is preferably rigid, but may also be either flexible or permanently bendable. A device can then be constructed by selection of a suitable set of tubing lengths, adapters and applicators. Devices customizable for particular uses can be created with minimal expense. The system is especially suitable for delivery of fluids to tissue in endoscopic or other minimally invasive surgical procedures. Delivery of fluids forming structure at a tissue site, especially as a hydrogel, is a preferred use of the devices.

Universal modular surgical applicator systems

This invention describes novel methods and devices for stabilizing and retracting tissue during surgery, in particular internal tissue. Patches of material, preferably biodegradable, are adhered to tissue surfaces. By manipulation of the patches, for example directly with forceps, or via sutures attached to the patches, tissues can be retracted or otherwise manipulated with minimal trauma to the tissues. The method is especially useful in minimally-invasive surgery.

Biodegradable tissue retractor

A gas powered spraying device that can be used for single or multi-part reactive medical polymer compositions is provided. A fluid or one or more reactive solutions are sprayed independently at a tissue surface, and the spraying of each solution of multi-component embodiments is controlled by a separate valve. Each solution is provided with a separate spray outlet, and each spray outlet is surrounded by an annular sheath of flowing gas. Gas flow is provided at two or more flow levels, including a high level flow for active spraying and a low level bypass flow to remove drips and prevent clogging, which can improve device reliability. Gas pressure can be used to drive fluid to its spray outlet, as well as to spray the fluid from the outlet to the tissue surface.

Self-cleaning fluid delivery device for medical applications

A device for testing the light power output of an optical system comprises a thermochromic element, a body element optionally providing collimation or other means of reproducible positioning, and optionally filters and attenuation. A preferred device fits onto the end of an optical power delivery system, and the thermochromic element changes color if the system output is above a defined threshold. An alternative device provides a flat target with a The device may be adapted to be sterilizable, and may be disposable. Optional means for ensuring that the light delivery system is operational during the measurement are provided.

Light source power tester

A closure for a bottle. The closure includes an outer cap. An audio device and a triggering mechanism are positioned within the outer cap. A water block is positioned on the outer cap so as to prevent water from penetrating into the audio device.

Audio closure

An impoved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitiator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as &ldquo;priming&rdquo;. The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, &ldquo;priming&rdquo; can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. A first surface and a barrier, or another surface, are prestained with initiator, and a thin layer of gelable monomer containing initiator is placed between them. Strong adhesion is obtained between the two surfaces on gelation of the monomer. In a similar fashion, tissue surfaces can be adhered to each other in repair of wounds and formation of anastomoses. Methods for use of non-photochemical systems and combined chemical/photochemical systems are described.

Redox and photoinitiator systems for priming for improved adherence of gels to substrates

This invention describes methods and devices for stabilizing and retracting tissue during surgery, in particular internal tissue. Patches of material, preferably biodegradable, are adhered to tissue surfaces. By manipulation of the patches, for example directly with forceps, or via sutures attached to the patches, tissues can be retracted or otherwise manipulated with minimal trauma to the tissues. The method is especially useful in minimally-invasive surgery.

Retracting tissue using photoadhering adhesive

Redox and photoinitiator systems for priming and improved adherence of

An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as 'priming'. The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, 'priming' can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. A first surface and a barrier, or another surface, are prestained with initiator, and a thin layer of gellable monomer containing initiator is placed between them. Strong adhesion is obtained between the two surfaces on gelation of the monomer. In a similar fashion, tissue surfaces can be adhered to each other in repair of wounds and formation of anastomoses. Methods for use of non-photochemical systems and combined chemical/photochemical systems are described.

Device for priming for improved adherence of gels to substrates

Growing community of inventors

Arlington, MA, United States of America

Dean M Pichon