Biosynthetic Technologies, LLC

Syngenta Participations Ag

Albemarle Corporation

Novartis Corporation

Novartis Crop Protection, Inc.

Dean Kent Hoglen

Eric Lee Williams

Travis Thompson

Marlon Lutz

Igor Likhotvorik

Chris Arnold

Andrea Rolf Sting

Denis Blaser

Dominik Faber

Heinz Peter Schwemlein

Herng-Tay Wu

Thierry Bourquard

Eric L Williams

The invention relates to a novel method for the preparation of 4-phenyldibenzo[b,d]thiophene which can be conducted in one pot up to the thiophene ring formation. The synthesis is based upon dihalobenzenes and phenyllithium, which are readily obtainable, and can give higher yields (based upon either reactant) than the yields current methods, which use a synthetic pathway based upon dibenzo[b,d]thiophene.

Process for the preparation of 4-phenyldibenzothiophene

Provided herein are processes of preparing sulfonated estolide compounds, and the removal of sulfonate residues from those compounds to provide desulfonated estolide base oils. Exemplary sulfonated estolide compounds include those selected from the formula: wherein z is an integer selected from 0 to 15; q is an integer selected from 0 to 15; x is, independently for each occurrence, an integer selected from 0 to 20; y is, independently for each occurrence, an integer selected 0 to 20; n is equal to or greater than 0; Ris selected from &#x2014;OH, optionally substituted alkyl, and optionally substituted aryl; and Ris selected from hydrogen and optionally substituted alkyl that is saturated or unsaturated, and branched or unbranched, wherein each fatty acid chain residue of said compounds is independently optionally substituted.

Processes of preparing estolide compounds that include removing sulfonate residues

The present invention relates to 3-substituted and 2,3-disubstituted pyridine compounds which are useful as intermediates in the synthesis of pyridylsulfonylurea herbicides. The invention also relates to arylation of alcohols using a pyridinediazonium salt. More particularly the arylation process of the instant invention relates to the synthesis of 2,3-disubstituted pyridine compounds via anhydrous diazotization of 3-amninopyridines to form a diazonium salt intermediate that is then reacted with the appropriate alcohol to produce the desired product. The invention additionally relates to pyridine-3-diazonium salt intermediates.

Diazonium salts which are intermediates for 3-substituted pyridines

The present invention relates to 3-substituted and 2,3-disubstituted pyridine compounds which are useful as intermediates in the synthesis of pyridylsulfonylurea herbicides. The invention also relates to arylation of alcohols using a pyridinediazonium salt. More particularly the arylation process of the instant invention relates to the synthesis of 2,3-disubstituted pyridine compounds via anhydrous diazotization of 3-aminopyridines to form a diazonium salt intermediate that is then reacted with the appropriate alcohol to produce the desired product. The invention additionally relates to pyridine-3-diazonium salt intermediates.

3-substituted pyridine compounds and related synthesis

2-chloro-3-hydroxypyridine is prepared by reacting 3-hydroxypyridine with aqueous sodium hypochlorite.

Process for the preparation of substituted pyridines

A method is provided for making ammelide ethers, such as a 2-amino-4,6-dialkoxy-1,3,5-triazine. A 2-amino-4,6-dihalo-1,3,5-triazine (ADXT) is synthesized in the presence of an aromatic organic solvent, and reaction is effected directly between the (ADXT) synthesis mixture and an alkali metal C.sub.(1-4) alkoxide and C.sub.(1-4) alkanol, including contact through a static mixer. These ammelide ethers are useful as intermediates for making N-phenylsulfonyl-N-triazinylureas, which have herbicidal and growth regulating properties.

Process for making 2-amino-4, 6-dialkoxy-1, 3, 5-triazines

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Baton Rouge, LA, United States of America

Dean Kent Hoglen