Heptares Therapeutics Limited

Dean Gordon Brown

Miles Stuart Congreve

Giles Albert Brown

Benjamin Gerald Tehan

Barry John Teobald

Shawn Donald Johnstone

Karl Henrik Edman

Hongming Chen

Roland Werner Burli

John Graham Cumming

Frank Xinhe Wu

The present application relates to certain substituted imidazole compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating pain, musculoskeletal inflammation, neuroinflammatory disorders, airway inflammation, itch, dermatitis, colitis and related conditions.

Inhibitors of protease-activated receptor-2

The present application relates to certain substituted imidazole and triazole compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating pain, musculoskeletal inflammation, neuroinflammatory disorders, airway inflammation, itch, dermatitis, colitis and related conditions. The compounds are of Formula (I) where X is N or CH, Z and Y are N or C (but both not N) and R-Rare as defined herein. 

Growing community of inventors

Waltham, MA, United States of America

Dean Gordon Brown