Baxter International Inc.

Baxter Travenol Laboratories, Inc.

Edwards Lifesciences Corporation

Dean G Laurin

Lecon Woo

Angeles Lillian Buan

William Anderson

Larry A Rosenbaum

Gregg Nebgen

Joseph P Hoppesch

Stanley Westphal

Denise S Hayward

Michael T Ling

Leonard F Czuba

Michael T K Ling

Lawrence F Becker

William D Johnston

Peter C Kwong

Yuan Pang Samuel Ding

Yuan Pang Ding

Richard J Johnson

Paul E Measells

Neng S Ung-Chhun

Marc C Bellotti

Crystal M Cunanan

Henry M Gajewski

Ronald C Stauber

Larry C Taylor

John E Kling

Byron Gleason

Ying Lo

J Barry Murtaugh

Archie G Woodworth

James Stupar

Lillian A Buan

Yuanpang Samuel Ding

Daniel R Boggs

Birendra K Lal

Chuan Qin

Patrick T Ryan

Joseph A Palomo

Donna L Rostron

Susan R Mizener

R Daniel Webster

John J Donohue

Crystal M Cunahan

Medical devices and methods of producing same are provided. The medical device comprising a body member and a coating on at least a portion of the body member comprising an insitu condensation product of a first electrophilically active, high molecular weight polyalkylene oxide and a second high molecular weight polyoxyalkylene derivative.

Medical devices and products having coatings applied thereto

Multiple component polymer compositions for fabrication into articles. In particular, polymeric compositions comprising a heat resistant polymer; a radio frequency ('RF') susceptible polymer; a compatibilizing polymer; the composition having physical properties within a range a&#x3c;40,000 psi; b&#x3e;=70%; c&#x3c;30%; d&#x3e;1.0; e&#x3c;0.1%; f&#x3c;0.1%; g&#x3e;=0.05; h&#x3c;=60%; i=0; wherein: a is the mechanical modulus of the composition measured according to ASTM D-882; b is the percent recovery in length of the composition after an initial 20% deformation; c is the optical haze of the composition being 9 mils in thickness according to ASTM D-1003; d is the loss tangent of the composition at 1 Hz measured at melt processing temperatures; e is the elemental halogen content by weight of the composition; f is the low molecular weight water soluble fraction of the composition; g is the dielectric loss between 1 and 60 MHz and over temperatures of 25 to 250&#xb0; C. of the composition; h sample creep measured at 121&#xb0; C. for a 1 inch strip of the composition under 27 psi loading; and, i indicates the composition exhibits no strain whitening after being strained at moderate speeds of about 20 inches (50 cm) per minute to about 100% elongation (twice the original length) and the presence of strain whitening (indicated by 1) or lack thereof (indicated by 0) is noted.

Polymeric compositions for medical packaging and devices

Method for producing improved medical devices and devices so produced

Multiple component polymer compositions for fabrication into articles. In particular, polymeric compositions comprising a heat resistant polymer; a radio frequency (&ldquo;RF&rdquo;) susceptible polymer; and a compatibilizing polymer.

A multiple layer structure comprising a skin layer composed of a polypropylene copolymer with styrene ethylene-butene styrene block copolymer within a range of 0-20% by weight skin layer, and, a radio frequency (&ldquo;RF&rdquo;) susceptible layer adhered to the skin layer. The RF layer has a first component of a propylene based polymer, a second component of a nonpropylene polyolefin, a third component of a radio frequency susceptible polymer, and a fourth component of a polymeric compatibilizing agent wherein the radio frequency susceptible polymer is selected from the group consisting of ethylene acrylic acid copolymers, ethylene methacrylic acid copolymers, polyimides, polyurethanes, polyesters, and polyureas.

Multi-layered polymer based thin film structure for medical grade products

A multiple layer structure comprising a skin layer composed of a polypropylene copolymer with styrene ethylene-butene styrene block copolymer within a range of 0-20% by weight skin layer, and, a radio frequency (&ldquo;RF&rdquo;) susceptible layer adhered to the skin layer. The RF layer has a first component of a propylene based polymer, a second component of a nonpropylene polyolefin, a third component of a radio frequency susceptible polymer, and a fourth component of a polymeric compatibilizing agent.

The present invention provides a method for fabricating flexible medical tubings comprising the steps of providing a tubing of a polymer material, the tubing having a longitudinal axis and an initial diameter, orienting the tubing along the longitudinal axis of the tubing to reduce the diameter of the tubing to define a oriented diameter, and applying heat to the oriented tubing to heat set the tubing to maintain dimensional stability of the tubing over a temperature to which the tubing will normally be exposed.

Heat setting of medical tubings

A multiple layer structure comprising a skin layer composed of a polypropylene copolymer with styrene ethylene-butene styrene block copolymer within a range of 0-20% by weight skin layer, and, a radio frequency ('RF') susceptible layer adhered to the skin layer. The RF layer has a first component of a propylene based polymer, a second component of a nonpropylene polyolefin, a third component of a radio frequency susceptible polymer, and a fourth component of a polymeric compatibilizing agent.

Multi-layered polymer structure for medical products

Multiple component polymer compositions for fabrication into articles. In particular, polymeric compositions comprising a heat resistant polymer; a radio frequency ('RF') susceptible polymer; a compatibilizing polymer; the composition having physical properties within the range a&lt;40,000 psi; b&gt;=70%; c&lt;30%; d&gt;1.0; e&lt;0.1%; f&lt;0.1%; g&gt;=0.05; h&lt;=60%; i=0; wherein: a is the mechanical modulus of the composition measured according to ASTM D-882; b is the percent recovery in length of the composition after an initial 20% deformation; c is the optical haze of the composition being 9 mils in thickness according to ASTM D-1003; d is the loss tangent of the composition at 1 Hz measured at melt processing temperatures; e is the elemental halogen content by weight of the composition; f is the low molecular weight water soluble fraction of the composition; g is the dielectric loss between 1 and 60 MHz and over temperatures of 25.degree. to 250.degree. C. of the composition; h sample creep measured at 121.degree. C. for a 1 inch strip of the composition under 27 psi loading; and, i indicates the composition exhibits no strain whitening after being strained at moderate speeds of about 20 inches (50 cm) per minute to about 100% elongation (twice the original length) and the presence of strain whitening (indicated by 1) or lack thereof (indicated by 0) is noted.

The coating of a RF active material on a non-RF active substrate material of typical thickness for packaging purposes, can generate sufficient thermal energy to effect strong bonding of the substrate materials. The RF active material may be-deposited on less than the entire inner surface area of the substrate material, preferably, at or near the portion of the substrate surface which represents the heat seal interface. In this manner of application, additional coating or printing of other substances on the substrate surface can be achieved without hampering the heat sealing process. Flexible medical containers capable of containing a product which is maintained and removed under sterile conditions, can be constructed on commercial production machines from these coated non-RF active substrate materials.

Method and compositions that render materials RF responsive

The coating of a RF active material on a non-RF active substrate material of typical thickness for packaging purposes, can generate sufficient thermal energy to effect strong bonding of the substrate materials. The RF active material may be deposited on less than the entire inner surface area of the substrate material, preferably, at or near the portion of the substrate surface which represents the heat seal interface. In this manner of application, additional coating or printing of other substances on the substrate surface can be achieved without hampering the heat sealing process. Flexible medical containers capable of containing a product which is maintained and removed under sterile conditions, can be constructed on commercial production machines from these coated non-RF active substrate materials.

An additive system for a polyvinyl chloride formulation for improved processability while maintaining thermal stability of the formulation, and having a low-water-blush haze and low extractability in an aqueous media, the additive system including a primary stabilizer which is a Lewis acid metal compound selected from the group consisting of organo-tin compounds and organo-zinc compounds, a secondary stabilizer selected from the group consisting of epoxide compounds having less than approximately 5.2 oxirane groups per molecule; and, an external lubricant for lubrication of the PVC formulation, wherein a critical ratio of the primary stabilizer to the secondary stabilizer maximizes thermolytic color stability while limiting generation of excessive build-up, plate-out, dark particles during the processing of the polyvinyl chloride formulation. And wherein the invention provides concentration levels of the stabilizers and an oxirane per molecule content of the secondary stabilizer which minimizes the extractbiles in aqueous media.

Additives for polymer compositions

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Lake Zurich, IL, United States of America

Dean G Laurin