Smithkline Beecham Corporation

Other

Dean E McNulty

Peter R Young

Peter C McDonnell

Jerry Leroy Adams

Timothy Francis Gallagher

James E Strickler

John Richard Heys

David W Green

John C Lee

Catherine E Ellis

Jeffrey S Culp

John Cheung-Lun Lee

Mark Robert Hurle

Craig Alan Rosen

Ivo Rogulia Siemens

Tian-Li Yue

This invention relates to drug binding proteins, to genes encoding same and to assays and methods for screening pharmaceuticals. More specifically, this invention relates to a Cytokine Suppressive Anti-Inflammatory Drug (CSAID) binding protein, to a gene encoding same and to assays and screens useful in the evaluation and characterization of drugs of this pharmacologic class.

Antibodies produced against cytokine suppressive anti-inflammatory drug binding proteins

Human Urotensin II polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human Urotensin II polypeptides and polynucleotides in therapy, and diagnostic assays for such.

Human urotensin II

Polynucleotides encoding cytokine suppressive anti-inflammatory drug

Isolated nucleic acid encoding human smooth muscle cell-derived migration factor, protein obtainable from the nucleic acid, recombinant host cells transformed with the nucleic acid and use of the protein and nucleic acid sequence are disclosed.

Smooth muscle cell-derived migration factor

Screening methods using cytokine suppressive anti-inflammatory drug

Cytokine suppressive anit-inflammatory drug binding proteins

Oligonucleotides comprising a region of a cytokine suppressive

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Philadelphia, PA, United States of America

Dean E McNulty