Glaxo Group Limited

Smithkline Beecham Corporation

Glaxo Wellcome Inc.

Glaxosmithkline Intellectual Property Development Limited

Dean David Edney

Keith Biggadike

Diane Mary Coe

Panayiotis Alexandrou Procopiou

Brian Edgar Looker

Stephen Barry Guntrip

Rajnikant Patel

Michael John Monteith

Rebecca Jane Moore

Abigail Halton

Gita Punjabhai Shah

Brian Cox

Malcolm Stuart Nobbs

Michael Simon Loft

Matthew Peter John

Andrew Kennedy

A novel process for the preparation of the compound of formula (II): which process comprises reacting a compound of formula (VI): with a compound of formula (IV): in a suitable solvent.

Process for the preparation of a biphenyl-2-yl carbamic acid ester

The present invention relates to novel compounds of Formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.

Methods using phenethanolamine derivatives for treatment of respiratory diseases

Phenethanolamine derivatives for treatment of respiratory diseases

The present invention relates to a process for the preparation of both the phenyl pyrazine derivative 2,6-diamino-3-(2,3,5-trichlorophenyl)pyrazine and an intermediate in the synthesis of 2,6-diamino-3-(2,3,5-trichlorophenyl)pyrazine, 2-&lcub;&lsqb;Cyano-(2,3,5-trichlorophenyl)-methyl&rsqb;-amino&rcub;-acetamidine or a salt thereof.

Process for the preparation of pyrazine compounds

Pyrazine compounds

A compound of formula (I) wherein R,is selected from the group consisting of phenyl substituted by one or more halogen atoms, naphthyl and naphthyl substituted by one or more halogen atoms; R,is selected from the group consisting of &mdash;NH,and &mdash;NHC(&boxH;O)R,; R,is selected from the group consisting of &mdash;NR,R,, &mdash;NHC(&boxH;O)R,and hydrogen, R,is selected from the group consisting of hydrogen, -C,alkyl, -C,alkyl substituted by one or more halogen atoms, &mdash;CN, &mdash;CH,OH, &mdash;CH,OR,and &mdash;CH,S(O),R,; wherein R,represents C,alkyl or C,cycloalkyl, and R,and R,, which may be the same or different, are selected from hydrogen and C,alkyl, or together with the nitrogen atom to which they are attached, form a,-membered nitrogen containing heterocycle, which heterocycle can be further susbtituted with one or more C,alkyl; R,is selected from C,alkyl or C,alkyl substituted by one or more halogen atoms; x is an integer zero, one or two; and pharmaceutically acceptable derivatives thereof; with the proviso that R,does not represent (a); when R,is &mdash;NH,, and both R,and R,are hydrogen.

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Dartford, United Kingdom

Dean David Edney