Colorado State University Research Foundation

Microbial Chemistry Research Foundation

Dean Calvin Crick

Michio Kurosu

Masayuki Igarashi

Patrick Joseph Brennan

Yoshimasa Ishizaki

A drug combination against acid-fast bacillus, including: an inhibitor for WecA or an ortholog thereof; and at least one of an inhibitor for MurX or an ortholog thereof and an RNA synthesis inhibitor, wherein the inhibitor for WecA or an ortholog thereof is used in combination with the at least one of an inhibitor for MurX or an ortholog thereof and an RNA synthesis inhibitor; a screening method for a drug against acid-fast bacillus; and an inhibitor for WecA or an ortholog thereof.

Combined anti-acid-fast bacterial agent, screening method for anti-acid-fast bacterial agents, and activity inhibitor of WecA or ortholog thereof

The invention provides compounds of the formula: or a pharmaceutically acceptable salt thereof, where m, n, R, R, RR, R, R, Rare those defined herein. The invention also provides pharmaceutical compositions comprising a compound of the invention, methods for using compounds and/or pharmaceutical compositions of the invention, and methods for synthesizing compounds of the invention. 

Compositions and methods of use of electron transport system inhibitors

The invention provides compounds that are useful as linkers for solid phase synthesis and as protecting groups, and methods for producing and using the same.

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Fort Collins, CO, United States of America

Dean Calvin Crick