Astrazeneca Ab

Dean Brown

Thomas Michael Bare

Rebecca Urbanek

Megan Murphy

Wenhua Xiao

Gary Steelman

Carey Horchler

Frances Marie McLaren

Edward Vacek

Christine Barlaam

Michael H Wood

Ashokkumar Bhikkappa Shenvi

Steven Sigmund Wesolowski

Phil Edwards

James Hulsizer

Dan Widzowski

M Edward Pierson, Jr

Vernon Alford

James R Damewood

James Campbell Muir

Abdelmalik Slassi

Methvin Benjamin Isaac

Andrew Griffin

Jalaj Arora

Scott Throner

Todd Andrew Brugel

James Arnold

Thierry Groblewski

Denis Labrecque

Michael Wood

M Edward Pierson Jr

Compounds the following formula: wherein Z is as described in the specification, pharmaceutically acceptable salts thereof, compositions comprising the same, and methods of treating bipolar disorder, an anxiety disorder, a mood disorder or schizophrenia or other psychotic disorder with said compounds.

Dibenzothiazepine derivatives and uses thereof&#x2014;424

Compounds of Formula I or pharmaceutically acceptable salts or solvates thereof: wherein Ar, Ar, A, X, Y, m, n and R, R, R, Rand Rare as described in the specification, processes for their preparation, pharmaceutical formulations comprising them and their use in therapy, particularly in the therapy of neurological and psychiatric disorders associated with glutamate dysfunction.

Piperazines and piperidines as Mglur5 potentiators

Compounds according to structural diagram (I) The following is an examiner's statement of reasons for allowance: In view of applicants' amendments to the claims which limit 'E' to phenyl or cycloalkyl groups the rejections of the previous action no longer pertain as they at best teach 'E' as alkyl.

1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-diones and their use for the treatment of pain

A compound, 7-chloro-4-hydroxy-2-(2-chloro-4-methylphenyl)-1,2,5,10-tetrahydropyridazino [4,5-b]quinoline-1,10-dione, pharmaceutically-acceptable salts thereof, a method for treating pain comprising administration of a pain-ameliorating effective amount of the compound and pharmaceutical compositions containing the compound.

Compound and method for the treatment of pain

A compound, 7-chloro-4-hydroxy-2-(2-pyridylethyl)-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione, its (&#x2212;) enantiomer, its (+) enantiomer, pharmaceutically-acceptable salts thereof, a method for treating pain comprising administering a pain-ameliorating effective amount of the (&#x2212;) enantiomer to an individual suffering from pain and pharmaceutical compositions containing the (&#x2212;) enantiomer are disclosed.

7-chloro-4-hydroxy-2-(2-pyridylethyl)-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione and the use thereof for the treatment of pain

Compounds useful for the treatment of pain in accord with structural diagram (I), or tautomers or pharmaceutically-acceptable salts of such compounds, wherein R and A are as disclosed in the specification. Also disclosed are methods for the treatment of pain using compounds according to structural diagram (I) and pharmaceutical compositions comprising compounds according to structural diagram (I).

1, 2, 5, 10-tetrahydropyridazino&lsqb;4, 5-b&rsqb;quinoline-1,10-diones and their use for the treatment of pain

A compound, 7-chloro-4-hydroxy-2-(2-chloro-4-methylphenyl)-1,2,5,10-tetrahydropyridazino&lsqb;4,5-b&rsqb;quinoline-1,10-dione, pharmaceutically-acceptable salts thereof, a method for treating pain comprising administration of a pain-ameliorating effective amount of the compound and pharmaceutical compositions containing the compound.

Compounds and methods for the treatment of pain

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Wilmington, DE, United States of America

Dean Brown