Sepracor, Inc.

Dean A Handley

Paul D Rubin

William E Yelle

Larry W Hardy

Merdad Varizi Parsey

Methods and compositions are disclosed utilizing hydroxyomeprazole for the treatment of ulcers in humans. Hydroxyomeprazole exhibits a lessened liability toward drug-drug interactions than omeprazole and a more predictable dosing regimen than omeprazole. Hydroxyomeprazole is also useful for the treatment of gastroesophageal reflux and other conditions related to gastric hypersecretion such as Zollinger-Ellison Syndrome.

Hydroxyomeprazole compositions

Hydroxyomeprazole compositions and methods

The invention relates to methods of utilizing descarboethoxyloratadine ('DCL') for the treatment of dermatitis. The invention also encompasses the topical administration of descarboethoxyloratadine using various dosage forms for the treatment of dermatitis.

Methods for treating dermatitis using descarboethoxyloratadine

Methods utilizing descarboethoxyloratadine ('DCL'), for the treatment of allergic disorders, while avoiding the concomitant liability of adverse side-effects associated with other non-sedating antihistamines. Also included are methods for the treatment of allergic asthma using DCL and either a decongestant or a leukotriene inhibitor, while avoiding the concomitant liability of adverse side-effects associated with other non-sedating antihistamines. The invention also encompasses the administration of DCL in a nasal or oral spray.

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Westborough, MA, United States of America

Dean A Handley