Anp Technologies, Inc.

De Chen

Ray Yin

Jing Pan

Dujie Qin

Yli Remo Vallejo, Jr

Thomas James Small

David Milunic

Remo Vallejo, Jr

Renee Street

Assays for detecting antibodies to pharmaceutical preparations, food allergens and environmental allergens are described.

Immunogenicity assay

A device and method for the rapid on-site detection of inhibitors of enzymes, such as acetylcholinesterase, is described wherein the device contains all reagents added to a sample pad containing dried releasable enzyme creating a reaction mixture wherein inhibitor deactivates the enzyme, while said reaction mixture travels via a longitudinal membrane to a distal porous pad containing a substrate for the enzyme. The reaction of the enzyme and the substrate results in a product that can generate a measurable signal such as color, fluorescence or luminescence to serve as a reporter. Signal that is generated at this reaction zone is inversely proportional to inhibitor concentration in the test sample. A device containing two such strips, one for a test sample, the other for a negative control fluid as an onboard comparator is described. A purpose-built reader or an illuminating device, such as, containing an incandescent light source, a diode, a UV light source or any other illumination source that is suitable for the reporter or mere visualization is used to determine the level of reporter.

One-step rapid assay for the detection of inhibitors of enzymes

Immunogenicity Assay

Multi-lateral flow assay strip carrier assembly

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Newark, DE, United States of America

De Chen