Regeneron Pharmaceuticals, Inc.

Dayong Guo

Andrew J Murphy

Gavin Thurston

Ka-Man Venus Lai

Kara Olson

Eric L Smith

Jesper Gromada

Eric B Smith

Viktoria Gusarova

Eric Smith

Kara L Olson

Non-human animals, expressing humanized CD3 proteins are provided. Non-human animals, e.g., rodents, genetically modified to comprise in their genome humanized CD3 proteins are also provided. Additionally, provided are methods and compositions of making such non-human animals, as well as methods of using said non-human animals.

Non-human animals expressing humanized CD3 complex

Non-human animals, and methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a humanization of an Angiopoietin-like protein 8 (ANGPTL8) gene. Said non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous ANGPTL8 locus so that said non-human animals express a human ANGPTL8 polypeptide.

Non-human animals having an engineered ANGPTL8 gene

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Overland Park, KS, United States of America

Dayong Guo