Warsaw Orthopedic, Inc.

Nuvasive, Inc.

Rti Biologics, Inc.

Regeneration Technologies, Inc.

Sdgi Holdings, Inc.

Rti Surgical, Inc.

Dayna Buskirk

Eric Christian Lange

Thomas V McGahan

Steven D DeRidder

John R Bianchi

Kevin C Carter

John F Wironen

Rodney Monroy

Michelle LeRoux Williams

James M Gross

Charles Randal Mills

Gina Scurti

Robert A Zambon

Earl Fender

C Randal Mills

Jamie M Grooms

Michael Esch

Chris Seid

P J Gorham

Thomas W Sander

Pat Coleman

Kevin Ross

Christopher A Seid

Harry W Rambo

Darren G Jones

A bone implant comprising cancellous bone that is essentially free of blood cells, and which has been treated with at least one loosening agent, such as collagenase or a digestive enzyme, for a time and at a concentration to loosen the osteogenic cells in the cancellous bone matrix. The osteogenic cells in the matrix are viable cells. The treatment of the cancellous bone with at least one loosening agent enables the osteogenic cells to be more available for carrying out their osteogenic function and to provide for an increased rate of bone formation. Such implant also may include demineralized bone, such as demineralized cortical bone, which enhances the bone regenerative capacity of the cancellous bone.

Cancellous bone product including viable osteogenic cells

This invention is directed to an assembled implant comprising two or more portions of bone that are held together in appropriate juxtaposition with one or more biocompatible pins to form a graft unit. Preferably, the pins are cortical bone pins. Typically, the cortical pins are press-fitted into appropriately sized holes in the bone portions to achieve an interference fit. The bone portions are allograft or xenograft.

Assembled implant

Instrument and implants are disclosed which provide for insertion of an implant into an intervertebral disc space from multiple approaches to the spine. Specifically, as a preferred aspect of the invention the implant includes a tapered portion and the implant may be inserted from multiple approaches to the spine with the orientation and taper properly oriented in the disc space regardless of the approach.

Anterior impacted bone graft and driver instruments

Disclosed herein is processed dermis graft for use in orthopedic surgical procedures. Specifically exemplified herein is a processed dermis graft comprising one or more bone blocks having a groove cut into the surface thereof, wherein said groove is sufficient to accommodate a fixation screw. Also disclosed is a method of processing dermis that results in a dermis derived implant suitable to replace a tendon or ligament in a recipient in need thereof. Other compositions and applications of a dermis derived implant, and methods of manufacture and use, are disclosed.

Soft and calcified tissue implants

This application provides a novel unitary bone implant having at least one rigid, mineralized bone segment, which may be machined to include threads, grooves, a driver head, perforations, a recess, or a symmetric shape, and a flexible, demineralized segment, which may also be machined to any desired shape prior to demineralization, or after demineralization. The disclosed implant has wide orthopedic applicability, including but not limited to repair or replacement of ligaments, tendons, and joints and for inducing vertebral fusions and fractured bone repair.

Segmentally demineralized bone implant

Growing community of inventors

Gainesville, FL, United States of America

Dayna Buskirk