East China Normal University

Daxiu Wei

Yefeng Yao

Jiaxiang Xin

Xue Yang

Huixia Liu

A pulse sequence method for realizing selective detection of multiple groups and/or molecules by simultaneously preparing nuclear spin singlets and/or singlet orders of the multiple groups and/or molecules. Taking an AGG molecule as an example, it is proposed to simultaneously prepare two pairs of uncoupled group signals of the AGG molecule into nuclear spin singlets and/or singlet orders, and eliminate magnetic resonance signals other than the nuclear spin singlets and/or singlet orders by using a pulsed gradient field, thereby realizing simultaneous selective observation of multiple group signals in the AGG molecule. Also disclosed is a method for simultaneously detecting group AGG-A in an AGG molecule and group Tau-C and group Tau-D in a Tau molecule. For the first time, the simultaneous preparation and signal selection of multiple nuclear spin singlets and/or singlet orders in a spin system is achieved. Compared with the conventional method, this method has higher sensitivity and better selectivity, and can further expand the application range of magnetic resonance.

Method for selectively detecting multiple groups and/or molecules simultaneously by preparing multiple nuclear spin singlet and/or singlet orders

A method uses the nuclear spin singlet of three hydrogen atoms on the dopamine benzene ring to achieve selective detection of dopamine signals in a complicated system. The present invention is based on magnetic resonance technology to detect dopamine, has good accuracy, sensitivity and selectivity, can accurately detect the signal of dopamine from the complicated system, and the interference of signals of other substances are well eliminated. Meanwhile, the present invention further has the advantages of simple operation and non-intervention, can be used for monitoring the content and distribution of the dopamine in a living body, and has important application value in the fields of biology and medicine.

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Shanghai, China

Daxiu Wei