Jiangsu Ruike Medical Science and Technology Co., Ltd.

Dawei He

Jianhua Chen

Wei Xiang

Yijiang Mei

Zengle Zhou

Zhidong Wan

Xiaodong Ma

Zhaobo Gao

Jingxin Lin

The invention relates to the field of pharmaceutical synthesis, in particular to a preparation method of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol derivatives and their intermediates. The preparation method is carried out starting from compound Formula A1.  In the preparation of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol derivatives, the chirality was constructed by enzymatic method, and the products were prepared with high optical purity. The preparation method can be used to produce the key intermediates of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol of darunavir commercially, which is a very economical route suitable for industrial production.

Method for preparing hexahydrofuro-furanol derivative, intermediate thereof and preparation method thereof

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Zhejiang, China

Dawei He