Samantree Medical Sa

Ecole Polytechnique Federale De Lausanne

Ecole Polytechnique Féderale De Lausanne (Epfl)

Davor Kosanic

Bastien Rachet

Etienne Shaffer

Juergen Brugger

Victor Cadarso

The disclosed technology brings histopathology into the operating theatre, to enable real-time intra-operative digital pathology. The disclosed technology utilizes confocal imaging devices image, in the operating theatre, 'optical slices' of fresh tissue&#x2014;without the need to physically slice and otherwise process the resected tissue as required by frozen section analysis (FSA). The disclosed technology, in certain embodiments, includes a simple, operating-table-side digital histology scanner, with the capability of rapidly scanning all outer margins of a tissue sample (e.g., resection lump, removed tissue mass). Using point-scanning microscopy technology, the disclosed technology, in certain embodiments, precisely scans a thin 'optical section' of the resected tissue, and sends the digital image to a pathologist rather than the real tissue, thereby providing the pathologist with the opportunity to analyze the tissue intra-operatively. Thus, the disclosed technology provides digital images with similar information content as FSA, but faster and without destroying the tissue sample itself.

Systems and methods for in-operating-theatre imaging of fresh tissue resected during surgery for pathology assessment

The present invention relates to a reflective optical objective () comprising: &#x2014;a first reflecting element () including a front surface () and a hack surface (), the front surface () including a convex reflecting surface (); and &#x2014;a second reflecting element () including a concave reflecting surface () facing the convex reflecting surface () of the first reflecting element (), the second reflecting element () including a transmissive section () permitting electromagnetic radiation to pass through the concave reflecting surface () of the second reflecting element () to the first reflecting element (). The reflective optical objective () is characterized in that the reflective optical objective () includes a carrier material () embedding at least the front surface () of the first reflecting element () and defining the distance (d) between the first () and second () reflecting elements.

Reflective optical objective

The disclosed technology brings histopathology into the operating theater, to enable real-time intra-operative digital pathology. The disclosed technology utilizes confocal imaging devices image, in the operating theater, 'optical slices' of fresh tissue&#x2014;without the need to physically slice and otherwise process the resected tissue as required by frozen section analysis (FSA). The disclosed technology, in certain embodiments, includes a simple, operating-table-side digital histology scanner, with the capability of rapidly scanning all outer margins of a tissue sample (e.g., resection lump, removed tissue mass). Using point-scanning microscopy technology, the disclosed technology, in certain embodiments, precisely scans a thin 'optical section' of the resected tissue, and sends the digital image to a pathologist rather than the real tissue, thereby providing the pathologist with the opportunity to analyze the tissue intra-operatively. Thus, the disclosed technology provides digital images with similar information content as FSA, but faster and without destroying the tissue sample itself.

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Lausanne, Switzerland

Davor Kosanic