Bristol-myers Company

Bristol-myers Squibb Compnay

Davis L Temple

Neil M Kurtz

Roger E Newton

Valentin K Gribkoff

Michael S Eison

Xina Nair

Stacy N Suberg

Steven I Dworetzky

Michael F Rafferty

Methods for the therapy of cystic fibrosis and multi-drug resistance in cancer chemotherapy by administering to a patient in need thereof 5-trifluoroethyl-1-(5-chloro-2-hydroxyphenyl)-1,3-dehydro-2H-benzimidazol- 2-one (NSOO4) or a pharmaceutically acceptable salt thereof.

Method for regulation of transmembrane chloride conductance

Tiospirone and its pharmaceutically acceptable salts are useful in alleviation of vascular or vascular-related headaches such as migraine, cluster, muscle-contraction, and combined headaches.

Method for alleviation of vascular headache

Gepirone and its pharmaceutically acceptable salts are useful in alleviation of panic disorders which can take the form of clinical syndromes comprising, for example, panic attacks, agoraphobia and phobic anxiety.

Gepirone for alleviation of panic disorders

Buspirone and its pharmaceutically acceptable salts are useful in alleviation of panic disorders which can take the form of clinical syndromes comprising, for example, panic attacks, agoraphobia and phobic anxiety.

Method for alleviation of panic disorders

New compositions using particular .beta..sub.2 agonists and vehicle materials have been prepared and are useful for producing a topical anti-inflammatory effect in mammals. The selected .beta..sub.2 agonists have previously not been known to exhibit topical anti-inflammatory activity. The compositions can be for example in the form of sprays, ointments, creams, gels, lotions, and suppositories, all of which are to be applied to the mammal topically, as opposed to systemically.

Growing community of inventors

Wallingford, CT, United States of America

Davis L Temple