Torrent Pharmaceuticals Limited

Davinder Tuli

Vijay Chauthaiwale

Ramesh Chandra Gupta

Laxmikant Chhipa

Shitalkumar Pukharaj Zambad

Ashok Kasundra

M Amir Siddiqui

Subrat Kumar Bhattamisra

Siralee Munshi

Chaitanya Dutt

C Dutt

The present invention discloses a novel thyroid like compounds of formula (I), wherein RR2, R, Rand Z are as defined in the specification, method for its preparation, composition containing such compounds and use of such compounds and composition as medicament. Further, compounds of formula (I) has significantly low binding affinity to thyroid receptors and thus considerably devoid of thyrotoxic effects. The invention also relates to the use of the compound of formula (I) for the preparation of a medicament for treating various disease conditions such as obesity, dyslipidemia, metabolic syndrome and co-morbidities associated with metabolic syndrome. 

Pyrazole-based thyroid receptor compounds

A novel thyroid like compounds of formula (I), wherein R, R, R, Rand Z are as defined in the specification, method for its preparation, composition and use thereof. Further, compounds of formula (I) has significantly low binding affinity to thyroid receptors and thus considerably devoid of thyrotoxic effects. The invention also relates to the use of the compound of formula (I) for the preparation of a medicament for treating various disease conditions including obesity, dyslipidemia, metabolic syndrome and co-morbidities associated with metabolic syndrome. 

Thyroid like compounds

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Gujarat, India

Davinder Tuli