Fidia Farmaceutici S.p.a.

Anika Therapeutics S.r.l.

Fidia Advanced Biopolymers S.r.l.

Fidia S.p.a.

Novagenit S.r.l.

Davide Bellini

Lanfranco Callegaro

Anna Maria Zanellato

Vittorio Crescenzi

Anna Taglienti

Cristina Longinotti

Alessandra Topai

Edgardo Cremascoli

Antonella Schiavinato

Andrea Francescangeli

Carlo Soranzo

Zefferino Righetto

Annamaria Paparella

Michael O'Regan

Doriana Senigaglia

Fabio Giusti

Marie Astier

Massimo Terrassan

The present invention relates to a method of preparing a composite biomaterial, essentially consisting of collagen in combination with granules of hydroxyapatite/&#x3b2;-tricalcium phosphate (HA/&#x3b2;-TCP), to be used in maxillofacial surgery, dentistry, aesthetic surgery and particularly in orthopedic surgery; the invention also relates to the biomaterial obtained by means of this method.

Method for preparing biocompatible and biodegradable biomaterials based on collagen and granules of hydroxyapatite/&#x3b2;-tricalcium phosphate for use in surgery, and biomaterials thus obtained

There is described a new non-woven fabric produced with the electrospinning technique, and the use thereof as new biomaterial for the biomedical and surgical field.

Biomaterials, their preparation by electrospinning and their use in the biomedical and surgical field

New biomaterials consisting of a combination of sulphated hyaluronic acid and gellan (as well as gellan that has not been associated with other polymers), to be used as a highly effective barrier to prevent post-surgical adhesions in abdominal, pelvic and, above all, spine surgery.

Biomaterials consisting of sulphated hyaluronic acid and gellan to be used in the prevention of spinal adhesions

An amide of hyaluronic acid or a derivative thereof which comprises at least one repetitive unit of general formula (I): wherein R=NRR, or alcoholic group of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, heterocyclic series, OH, O&#x2014;, alcoholic group of hyaluronic acid, amino group of deacylated hyaluronic acid; R, R, R, R=H, SO&#x2014;, acyl group derived from a carboxylic acid of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, heterocyclic series, &#x2014;CO&#x2014;(CH)&#x2014;COOY; Y=negative charge, or H; R=&#x2014;CO&#x2014;CH, H, SO&#x2014;, acyl group derived from a carboxylic acid of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, heterocyclic series, acylic group of hyaluronic acid; R=is H or a aliphatic, aromatic, arylaliphatic, cycloaliphatic, or heterocyclic group, substituted or unsubstituted; R=is H or an aliphatic, aromatic, arylaliphatic, cycloaliphatic, or heterocyclic group, substituted or unsubstituted; wherein at least one of R or Rforms an amide group.

Amides of hyaluronic acid and the derivatives thereof and a process for their preparation

The present invention relates to novel formulations comprising lipoic acid and hyaluronic acid and/or the derivatives thereof for use in the repair of chronic ulcers, the regeneration of damaged skin, the prevention of skin aging and, when administered by the systemic route, to treat peripheral neuropathies and intoxications by chemical and/or biological agents.

Formulations of lipoic acid and hyaluroinc acid and/or the derivatives thereof in the pharmaceutical and cosmetic fields

The present invention relates to hyaluronic acid ester derivatives, whose carboxylic groups are partially esterified with hydroxy groups of propiophenone derivatives, to the hydrogel materials consisting of the said hyaluronic acid ester derivatives, to their preparation process by photocuring of the hyaluronic acid ester derivatives, and their use in the biomedical, sanitary and surgical fields, and in the medical field as controlled release systems for drugs.

Ester derivatives of hyaluronic acid for the preparation of hydrogel materials by photocuring

An amide of hyaluronic acid or a derivative thereof which comprises at least one repetitive unit of general formula (I): wherein R&#x2550;NRR, or alcoholic group of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, heterocyclic series, OH, O&#x2014;, alcoholic group of hyaluronic acid, amino group of deacylated hyaluronic acid; R, R, R, R&#x2550;H, SO&#x2014;, acyl group derived from a carboxylic acid of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, heterocyclic series, &#x2014;CO&#x2014;(CH)&#x2014;COOY; Y&#x2550; negative charge, or H; R&#x2550;&#x2014;CO&#x2014;CH, H, SO&#x2014;, acyl group derived from a carboxylic acid of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, heterocyclic series, acylic group of hyaluronic acid; R&#x2550; is H or a aliphatic, aromatic, arylaliphatic, cycloaliphatic, or heterocyclic group, substituted or unsubstituted; R&#x2550; is H or an aliphatic, aromatic, arylaliphatic, cycloaliphatic, or heterocyclic group, substituted or unsubstituted; wherein at least one of R or Rforms an amide group.

Amides of hyaluronic acid the derivatives thereof and a process for their preparation

The present invention concerns amide derivatives of hyaluronic acid (HA) and biomaterials made of amide derivatives of hyaluronic acid (HA), particularly the hexadecylamide of HA, administered by the intra-articular route as a partial/total substitute for synovial fluid to treat joints affected by osteoarthrosis (OA) as well as cases of joint inflammation and/or trauma that cause damage to the cartilage and/or synovia (associated with pain). Lastly, we describe and claim their use in the treatment of joints where the entire structure shows signs of wear due to physiological aging.

Amide derivatives of hyaluronic acid in osteoarthrosis

The present invention relates to percarboxylated polysaccharide selected from the group consisting of gellan, carboxymethylcellulose, pectic acid, pectin and hyaluronic acid derivatives; the process for their preparation and their use in the pharmaceutical, biomedical, surgical and healthcare fields.

Percarboxylated polysaccharides, and a process for their preparation

The present invention relates to hyaluronic acid ester derivatives, whose carboxylic groups are partially esterified with hydroxyl groups of propiophenone derivatives, to the hydrogel materials consisting of the said hyaluronic acid ester derivatives, to their preparation process by photocuring of the hyaluronic acid ester derivatives, and their use in the biomedical, sanitary and surgical fields, and in the medical field as controlled release systems for drugs.

The application discloses esters of hyaluronic acid, wherein a first part of the carboxylic functions is esterified with an araliphatic alcohol and a second part is esterified with at least one long-chain, straight aliphatic alcohol with between 10 and 22 carbon atoms. The possible remaining non-esterified carboxylic functions, if present, are salified. The application further discloses biocompatible threads having a multifilament conformation comprising filaments formed by the aforesaid esters, and their use in the fields of medicine and surgery.

Hyaluronic acid esters, threads and biomaterials containing them, and their use in surgery

The present invention relates to compositions containing an autocross-linked form of hyaluronic acid as a first component in a mixture with a second component noncross-linked hyaluronic acid, and possibly also in combination with another pharmacologically active substance. These compositions can be used in the treatment of arthropathies due to their unique viscoelastic properties.

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Albignasego, Italy

Davide Bellini