Yeda Research and Develpment & Co. Ltd

Other

Mor Research Applications Ltd.

David Zbaida

Meir Lahav

Karlheinz Drauz

Reshef Tenne

Matthias Kottenhahn

Guenter Knaup

Lia Addadi

Margherita Morpurgo

Racheli Ron

Ilan Kafka

Ilan Leibovitch

Isabelle Weissbuch

Edna Shavit

Amnon Buxboim

Maya Bar-Dagan

A new approach is presented to reduce encrustation of catheters by the application of nanoparticles. It is demonstrated that the negatively surface charged nanoparticles produce coating films comprised of long-range domains in which the nanoparticles are self-assembled into a mosaic-like order, showing a relatively small tendency to agglomerate.

Attenuation of encrustation of medical devices using coatings of inorganic fullerene-like nanoparticles

The present invention relates to a process for the resolution of DL-racemic mixtures of compounds which crystalize in the form of a conglumerate. Both, the D and L-enantiomers are obtained according to the invention in a industrially feasable process by adding chiral enantioselective polymers to the supersaturated solution of the racemat to inhibit crystalization of one enantiomer. Next a DL-racemic mixture of said compound is suspended in about twice the amount of the crystallized enantiomer. Consequently, the opposite enantiomer could be recovered by said suspension by physical separation.

Resolution of DL-racemic mixtures

The invention relates to a process for the kinetic resolution of D,L-racemic mixtures of racemates crystallizing as conglomerates. Resolution is effected from supersaturated solutions of these which is carried out in the presence of a polymer bound inhibitor of crystallization of the one form, resulting in the preferred crystallization of the one form, and when the other form is desired - in the presence of such inhibitor for the other form. Amongst racemic mixtures amenable to this process are amino acids. The process can be carried out in a two-compartment device, where the compartments are separated by a membrane which is permeable to the constituents of the racemate, while it is impervious to the polymer-bound inhibitor for the crystallization of one of the racemic forms.

Process for the resolution of D,L-racemic mixtures

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Givataim, Israel

David Zbaida