Varco I/p, Inc.

Trio Medicines Limited

Cellcentric Limited

David Wood

Donald Alan Gilbert

Kenneth W Seyffert

George Alexander Burnett

James Michael McIntosh

Malcolm James Boyce

Liv Thomsen

Colin Crabb

William Christian Herben

David Michel Adrien Taddei

Gareth Harbottle

Paul Baguley

Colin Lindley

John Paul Madeley

James Vaughan Morey

Jonathan Trevorrow

William Chrtistian Herben

Kenneth Wayne Seyffert

James Michael Mcintosh

A process for producing a compound of the following formula (I) which process comprises: (a) treating a compound of the following formula (5) with a compound of the following formula (6) to generate an intermediate compound of the following formula (7); (b) treating a compound of formula (7) as defined above with a compound of the following formula (8); and (c) recovering a compound of formula (I) as defined above. The compound of formula (I) is a promising modulator of p300/CBP activity that has potential utility in treating cancers, including prostate cancer, haematological cancers, bladder cancer and lung cancer. 

Process for preparing modulators of p300 and/or CBP

The invention relates to processes for the synthesis of benzodiazepine derivatives of Formula I: 

Synthesis of benzodiazepine derivatives

The invention relates to benzodiazepine derivatives of formula (A) useful as CCK/gastrin receptor antagonists, their preparation and their use in the treatment or prevention of disorders associated with CCK/gastrin receptors, disorders caused by or associated with hypergastrinaemia, and gastric acid-related disorders. 

Benzodiazepine derivatives as CCK2/gastrin receptor antagonists

The invention relates to processes for the synthesis of benzodiazepine derivatives of Formula I: (I) 

Vessels, system and methods for conveying drilling cuttings material, which, in certain aspects, include a system for conveying material from a vessel, the system having a vessel for receiving material to be conveyed, a first conduit for conveying air, a second conduit for receiving air from the first conduit and for conveying air into the vessel, a metering screw for receiving material from the vessel and for moving the material from the vessel, a discharge line for receiving the material from the metering screw, the discharge line having an exit end, pressure sensor apparatus for sensing pressure in the discharge line, and control apparatus for automatically controlling the metering screw in response to a pressure sensed by the pressure sensor apparatus.

Drill cuttings conveyance systems and methods

Methods for processing drill cuttings including measuring moisture content of the drill cuttings; systems for doing this; methods for moving drill cuttings using conduits with spaced-apart inlets for applying positive pressure; and feeding apparatuses for loading drill cuttings into a positive pressure conduit.

Vessels for selectively holding drilling cuttings material and methods employing such vessels; the vessels, in at least certain aspects, having a body with a hollow container with an interior space for receiving drilling cuttings material and from which the material may exit from the body; a first opening through which the material enters into the container; a second opening through which the material passes out from the container; and movement apparatus with a movement member within the container movable adjacent the second opening to facilitate passage of the material into the second opening; and in certain aspects, the vessels having moisture-content sensor apparatus on the body for sensing moisture content of material within a vessel; conduit apparatus for conducting drilling cuttings from the exit opening; valve apparatus for selectively controlling flow of material in the conduit apparatus; and a controller in communication with the moisture-content sensor apparatus and the valve apparatus for selectively controlling flow in the conduit apparatus.

Systems and methods for storing and handling drill cuttings

Methods for moving drilled cuttings, the methods, in certain aspects, using a cuttings processor with a rotating annular screen to separate fluid from drilled cuttings and/or such methods including conveying with air under positive pressure, drilled cuttings to flow conduit apparatus; applying air under positive pressure to the flow conduit apparatus to continuously move the drilled cuttings material therethrough; continuously moving the drilled cuttings material with the air under pressure to separation apparatus; with the separation apparatus continuously separating drilled cuttings from air; wherein, in certain aspects, the drilled cuttings are included in a low density slurry with drilling fluid, drilling mud, and/or oil and wherein, in certain aspects, the separation apparatus is a cyclone separator and the drilled cuttings moved into the cyclone separator are wet; and systems for effecting such methods.

Growing community of inventors

Sudbury, United Kingdom

David Wood