Convergence Pharmaceuticals Limited

Bicycletx Limited

Galapagos Nv

Calchan Limited

Glaxo Group Limited

David Witty

David MacPherson

Gerard M P Giblin

Steven J Stanway

Kevin McDonnell

Paul John Beswick

Gemma Elizabeth Mudd

David Norton

Katerine Van Rietschoten

Michael Skynner

Gabriela Ivanova-Berndt

Jason Tierney

Ghislaine Lorthioir

Mairi Sime

Karen Louise Philpott

Michael John Williams

Christopher Norbert Johnson

Mervyn Thompson

Gordon Saxty

Karl Richard Gibson

Milan Mesic

Stephen Frederick Moss

Gregor James MacDonald

David Amantini

William F Kiesman

Mahmood Ahmed

Charles Edward Wade

Martin C Jones

Dinko Ziher

Tamera L Mack

Tanja Poljak

Gerard Giblin

Donald Walker

Ines Vujasinovic

Gregor James Macdonald

Tamera Mack

The present invention provides compounds, compositions thereof, and methods of using the same.

Bicyclic peptide ligands and uses thereof

The present invention relates to pyrrolopyrimidine compounds according to Formula I and their use in the prophylaxis and/or treatment of pain, inflammatory conditions, cardiovascular diseases, neurodegenerative diseases, neurological diseases, complications of type I diabetes, cancer and/or fibrotic diseases. In a particular aspect, the present compounds are ASK inhibitors, particularly ASK1 inhibitors. The present invention also provides methods for the production of a compound of the invention, pharmaceutical compositions comprising a compound of the invention, the use of the compounds in the prophylaxis and/or treatment of pain, inflammatory conditions, cardiovascular diseases, neurodegenerative diseases, neurological diseases, complications of type I diabetes, cancer and/or fibrotic diseases. 

Pyrrolopyrimidine and pyrrolopyridine derivatives

The invention relates to a novel process for preparing &#x3b1;-carboxamide pyrrolidine derivatives, in particular (2S, 5R)-5-(4-((2-fluorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamide, and to novel intermediates for use in said process along with processes for preparing said intermediates.

Process for preparing alpha-carboxamide pyrrolidine derivatives

The invention relates to spiro deriviatives, to the use of said derivatives in treating diseases and conditions mediated by modulation of voltage-gated sodium channels, to compositions containing said derivatives and processes for their preparation.

Pyrimidinyl-diazospiro compounds

The invention relates to spiro derivatives, to the use of said derivatives intreating diseases and conditions mediated by modulation of voltage-gated sodium channels, to compositions containing said derivatives and processes for their preparation.

This invention relates to pyrrolopyrimidine derivatives of formula (I): where R, X, p, R, Rand Rare as defined herein, and their use as pharmaceuticals. 

ASK1 inhibiting pyrrolopyrimidine derivatives

The invention relates to spiro derivatives, to the use of said derivatives in treating diseases and conditions mediated by modulation of voltage-gated sodium channels, to compositions containing said derivatives and processes for their preparation.

ASK 1 inhibiting pyrrolopyrimidine derivatives

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Cambridge, United Kingdom

David Witty