Amersham Pharmacia Biotech UK Limited

David Williams

Daniel M Brown

Shiv R Kumar

Mark McDougall

Satyam Nampalli

David Loakes

Clifford Leslie Smith

Adrian Christopher Simmonds

Alan L Hamilton

William Jonathan Cummins

Fergal Hill

Patrick Finn

Ermanno Gherardi

Manuella Carla Zaccolo

Nucleoside analogues have structure (2) wherein Q is H or a sugar moiety or sugar analogue or a modified sugar or a nucleic backbone or backbone analogue, W is an alkylene or alkenylene chain of 0-5 carbon atoms, any of which may carry a substituent R , X is O or N or NR or CR , X&prime; is O or S or N, provided that when X&prime; is O or S, then X is C, Y is CH or N, R is NH or SMe or SO Me or NHNH , each of R and R is independently H or F or alkyl or alkenyl or aryl or acyl or a reporter moiety, R is independently H or alkyl or alkenyl or aryl or acyl or a reporter moiety, and R is H or &boxH;O or F or alkyl or aryl or a reporter moiety.

Tricyclic base analogues

Relating to mutagenesis of nucleic acids

Growing community of inventors

Sheffield, United Kingdom

David Williams