University Hospital of Basel

Cellec Biotek Ag

Millenium Biologix Technologies Inc.

Octane Biotech Inc.

David Wendt

Ivan Martin

Francesco Giovanni Greco

Adam Papadimitropoulos

Rodolfo Quatro

Alessandra Braccini

Laura Spinelli

Stefania Adele Riboldi

Marcel Jakob

Elia Piccinini

Peter Iwatschenko

A bioreactor for preferably three-dimensional cell culturing comprises a scaffold chamber, a first tube, a second tube and a first valve with a scaffold adapter, a tube adapter and a medium adapter. The first valve has a housing with a longitudinal female portion ending in an opening and a longitudinal actuator being arranged through the opening of the female portion of the housing such that the actuator is arranged partially inside the housing and partially outside the housing, wherein the actuator of the first valve is axially moveable relative to the housing of the first valve between a first position in which the first valve is in the operation position and a second position in which the first valve is in the medium change position. By providing the actuators in the first valve which is applied by axial movements, operation of the bioreactor can be comparably simple and safe.

Bioreactor and rack for mounting bioreactors

The invention is a reverse-flow method and system for the loading, proliferation and differentiation of cells into and throughout an implantable biocompatible three-dimensional scaffold.

Reverse flow perfusion of three-dimensional scaffolds

Growing community of inventors

Arlesheim, Switzerland

David Wendt