Curium US LLC

Mallinckrodt Nuclear Medicine LLC

David Wayne Pipes

William Claude Uhland

Lauren Radford

Brian Regna

Craig Brunkhorst

Melissa Dianne Perrigo

Shaun Loveless

Mark Owens

Allan Casciola

William C Uhland

Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.

Purification process for the preparation of non-carrier added copper-64

The present disclosure relates to methods to create a robust procedure capable of supplying commercial quantities of a radioactive diagnostic agent indicated for use with positron emission tomography (PET) for localization of somatostatin receptor positive neuroendocrine tumors (NETs) in adult patients.

Radiolabeling and formulation for scale up ofCu-DOTATATE

The present disclosure generally relates to a new process for generating germanium-68 from an irradiated target body. The process includes irradiation of the target body followed by various extraction techniques to generate the germanium-68.

Process of generating germanium

Processes for producing germanium-68 from a gallium target body are disclosed. In some embodiments, germanium-68 and gallium are precipitated to remove metal impurities. Germanium-68 and gallium are re-dissolved and loaded onto an ion exchange column to separate germanium-68 from gallium.

Processes for generating germanium-68 with reduced volatiles

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Wildwood, MO, United States of America

David Wayne Pipes