Abbott Laboratories Corporation

Abbvie Inc.

Abbvie Biotechnology Ltd

D.e. Shaw Research, LLC

Other

Abbott Biotechnology Ltd.

David Wayne Borhani

Gerhard Winter

Wolfgang Fraunhofer

Stefan Gottschalk

Hans-Juergen Krause

Anette Koenigsdorfer

David J Calderwood

Kristine E Frank

Richard W Dixon

Morten Østergaard Jensen

Vishwanath Jogini

Anna M Ericsson

Kurt Ritter

Gavin C Hirst

Thomas D Gordon

Neil Wishart

Maria A Argiriadi

Biqin C Li

Lu Wang

Kelly Mullen

Kevin Patrick Cusack

Andrew Burchat

Robert V Talanian

Peter Hrnciar

Heather M Davis

Xiaoyun Wu

Nathan Josephsohn

Claude E Barberis

Lily K Abbott

Xiaolei Zhang

Barbara S Skinner

Andreas Loew

Adelaine Leung

In one aspect, the invention relates to a method for identifying a compound which modulates the activity of a voltage-gated protein. In certain embodiments, the voltage gate protein is a voltage-gated ion channel. In certain embodiments, the voltage-gated protein is a voltage sensitive phosphatase. In certain embodiments, the voltage-gated protein used in conjunction with the methods of the invention is modified to altered permeability or voltage sensitivity.

Methods for screening voltage-gated proteins

The invention relates to batch crystallization methods for crystallizing an anti-hIL-12 antibody that allows the production of the antibody on an industrial scale, antibody crystals obtained according to the methods, compositions containing the crystals, and methods of using the crystals and the compositions.

Crystalline anti-human IL-12 antibodies

The present invention relates to a batch crystallization method for crystallizing an anti-hTNFalpha antibody which allows the production of said antibody on an industrial scale; antibody crystals as obtained according to said method; compositions containing said crystals as well as methods of use of said crystals and compositions.

Crystalline anti-hTNFalpha antibodies

The present invention relates to a batch crystallization method for crystallizing anti-human TNFalpha (hTNFalpha) antibody and antibody fragments which allows the production of said antibody on an industrial scale; a method of controlling the size of antibody crystals, for example, crystals of anti-hTNFalpha antibody fragments, compositions containing said crystals as well as methods of use of said crystals and compositions.

Compositions and methods for crystallizing antibodies

Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.

Indazole compounds

The present invention is directed to novel compounds of formula (I) wherein the variables are as defined herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.

Imidazothiazoles and imidazoxazoles

The present invention relates to polypeptides which comprise the ligand binding domain of Lck, crystalline forms of these polypeptides, and the use of these crystalline forms to determine the three dimensional structure of the catalytic domain of Lck. The invention also relates to the use of the three dimensional structure of the Lck catalytic domain both alone, or in complex with inhibitors, in methods of designing and/or identifying potential inhibitors of Lck activity, for example, compounds which inhibit the binding of a native substrate to the Lck catalytic domain. The invention also relates to the use of the three dimensional structure of the Lck catalytic domain both alone, or in complex with inhibitors, in methods of designing and/or identifying potential selective inhibitors of Lck activity, for example, compounds which inhibit the binding of a native substrate to the Lck catalytic domain selectively.

Method of identifying inhibitors of Lck

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Hartsdale, NY, United States of America

David Wayne Borhani