Koninklijke Philips Corporation N.v.

Siemens Healthineers Nederland B.v.

David Walterus Cornelis Dekkers

Toon Hendrik Evers

Wendy Uyen Dittmer

Joost Lambert Max Vissers

Peggy De Kievit

Ricky Kamps

Marco Hendrikus Hefti

An immunoassay for the detection of an analyte in a sample includes a plurality of moieties capable of binding to the analyte. Capture moieties, which are not specific for the same epitope, are bound to a solid substrate, and at least one epitope-specific detection moiety is bound to a detectable marker. The detectable marker is a large particle marker having a particle size of &#x2265;50 nm and &#x2264;5000 nm.

Highly sensitive immunoassay with large particle labels

The present invention relates to a method for measuring Troponin I in a sample comprising the steps of providing a sample, contacting the sample with a monoclonal anti-Troponin I antibody coupled to a magnetic label, contacting the sample with a polyclonal anti-Troponin I antibody coupled to a sensor surface and detecting the magnetic label on the sensor surface. The invention further relates to a device and a cartridge for measuring Troponin I in a sample.

Assay for Troponin I using magnetic labels

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Veldhoven, Netherlands

David Walterus Cornelis Dekkers