Yeda Research and Develpment & Co. Ltd

Other

The Weizmann Institute of Science

Ben-gurion University of the Negev Research and Development Authority

Hadasit Medical Research Services and Development Ltd.

Yeda Research and Development Ltd.

David Wallach

Igor Mett

Hartmut Engelmann

Mark Boldin

Eugene Varfolomeev

Andrei Kovalenko

Cord Brakebusch

Dan Aderka

Parameswaran Ramakrishnan

Tanya Goncharov

Menachem Rubinstein

Michel Revel

Igor Beletsky

Jacek Bigda

Taisia Shmushkovich

Oliver Kemper

Daniela Novick

Nikolai Malinin

Elena Appel

Zeev Pancer

Vadim Brodianski

Louise Chen

Michael Batkin

Peter Kuhnert

Yura Goltsev

Zelig Eshhar

Adi Kimchi

Yury V Golstev

Marcus Schuchmann

Rinat Abramovitch

Marshall S Horwitz

Rom Eliaz

Josef Kost

Giuseppina Cantarella

Indranil Sinha

Lester Shulman

Mordecai Gasul

Daniel Boyko

Gotz Ehrhardt

Yaron Nophar

Harmut Engelmann

Yasmin Maor

Helmut Holtmann

Tanya Goncahrov

Talia Hahn

Parameswaran Makrishnan

Rajput Akhill

Stefan Leu

Nikolay Malinin

Mark Boldiin

Tania Goncharov

Ganesh Kolumam

Akhil Rajput

Wangxia Wang

Wang Wangxia

Hila Barash

Tehila Ben Moshe

Eitan Galun

Yongan Li

Taisa Shmushkovich

Jin Chul Kim

Yury Goltsev

An antibody or antibody preparation being capable of specifically binding the amino acid sequence of NF-&kgr; B-inducing kinase (NIK) MAP3K14, or a specific portion thereof, and of thereby regulating a biochemical activity of NIK, and/or enabling detection of NIK or a specific portion thereof.

Anti-NIK antibodies and uses thereof

The present invention relates to a splice variant of SIVA, SIVA3, and to its use.

SIVA 3, its preparation and use

The present invention provides a chimeric protein capable of killing or modifying a cell expressing abnormally high levels of a ligand of a receptor of the TNF/NGF family, comprising the amino acid sequence of at least one polypeptide consisting of an extracellular portion of said receptor connected to an effector molecule. In addition the invention provides pharmaceutical compositions comprising said chimeric protein and use thereof.

Chimeric proteins and uses thereof

A method of treating a disease associated with NF-&#x3ba;B activity. The method is effected by providing to a subject in need thereof a therapeutically effective amount of an agent capable of modulating NIK-HC8 binding.

Pharmaceutical compositions for treating diseases associated with NF-&#x3ba;B activity

The invention relates to the use of NF-&#x3ba;B inducing kinase (NIK) and related molecules for the modulation of signal activities controlled by cytokines, and some new such molecules.

Derivatives of the NF-&#x3ba;B inducing enzyme, their preparation and use

The invention relates to caspases and to extracellular use of caspases for regulating cell functions.

Method of treating a disease by administering caspase-8

The present invention relates to the regulatory role of caspase-8 in infection by intracellular pathogen, inflammation and wound healing.

Caspase-8 and inflammation, infection and wound healing

The present invention relates to the ubiquitination and/or degradation-related activity of a SIVA polypeptide and to agents capable of modulating said activity.

SIVA ubiquitination and/or degradation-related activity and modulators thereof

A DNA sequence encoding a protein capable of binding to a tumor necrosis factor receptor-associated factor (TRAF) molecule, TRAF-binding proteins, their isoforms, analogs, fragments and derivatives encoded by the DNA sequence, their methods for the production of the DNA sequences and proteins, and the uses for the DNA sequence and proteins.

Modulators of TNF receptor associated factor (TRAF), their preparation and use

An isolated DNA molecule has the sequence of encoding a fragment of encoding Tumor Necrosis Factor (TNF) Binding Protein II. It has a length sufficient to serve as an immunogen for raising antibodies against a polypeptide that is a fragment of TNF Binding Protein II. The DNA may be used to produce replicable expression vehicles and prokaryotic or eukaryotic expression host cells. Such host cells may be used to produce polypeptides encoded by such DNA molecules.

Isolated cDNA encoding tumor necrosis factor binding protein II, its purification, and vectors, hosts and processes using such cDNA

The present invention relates to a chimeric protein comprising a cell-targeting agent and aouter protein, connected by a translocating polypeptide. The invention further relates to the preparation and use of such chimeric protein.

Chimeric proteins, their preparation and pharmaceutical compositions containing them

This invention relates to the use of the IL-2 common gamma (c&#x3b3;c) and related molecules for the modulation of signal activities controlled by NIK, and some new such molecules.

Derivatives of the IL-2 receptor gamma chain, their production and use

Methods and agents for immune modulation and methods for identifying putative immune modulators are provided.

Method for treating an immune disorder by decreasing NIK-SIVA complex formation

The present invention provides proteins capable of modulating or mediating the FAS receptor ligand or TNF effect on cells carrying FAS receptor or p55 receptor by binding or interacting with MORT-1 protein, which in turn binds to the intracellular domain of the FAS receptor or to another protein TRADD which binds to the p55 receptor. In addition, peptide inhibitors that interfere with the proteolytic activity of MORT-1-binding proteins having proteolytic activity are provided, as well as a method of designing them.

Modulators of the function of FAS receptors and other proteins

The present invention relates to a protein, designated NAP (Nemo Associated Protein), that was discovered to inhibit the activation of transcription factor NF-kB by various signals that are important in inflammatory and immune processes. The DNA and the recombinant production of this protein is also disclosed as well as methods of using the protein or encoding DNA.

Inhibitor of NF-KB activation

Growing community of inventors

Rehovot, Israel

David Wallach