Other

Biomolecular Products, Inc.

Children's Hospital Los Angeles

David W Yesair

Walter Allen Shaw

Stephen W Burgess

Robert Travis McKee

Barry J Maurer

C Patrick Reynolds

Charles Patrick Reynolds

Barry James Maurer

Robert Travis Mckee

Travis Mckee

Travis Robert Mckee

Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase Aare provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride and fatty acid, and lipid matrices of particular structure.

Modifications of solid 3-sn-phosphoglycerides

The present invention provides an edible composition for oral delivery of an active agent such as a retinide. The composition comprises, in the form of a dry flowable powder: (a) an active agent such as a retinide; (b) lipid matrix composition; (c) optionally sweetener; (d) flour. Compositions of the invention may be administered per se or mixed with a solid or liquid food carrier, for direct oral consumption by a subject or administration through a feeding tube.

Oral compositions of fenretinide having increased bioavailability and methods of using the same

The present invention provides an edible composition for oral delivery of an active agent such as paclitaxel or a retinide. The composition comprises, in the form of a dry flowable powder: (a) an active agent such as a retinide; (b) lipid matrix composition; (c) optionally sweetener; (d) flour. Compositions of the invention may be administered per se or mixed with a solid or liquid food carrier, for direct oral consumption by a subject or administration through a feeding tube.

Oral pharmaceutical compositions and methods of using the same

Modification of solid 3-sn-phosphoglycerides

This invention provides a composition and method for increasing fat absorption from the intestine by increasing the amount of lysophosphatidylcholine in the intestine. The composition comprises phospholipase A and lipid molecules.

Method and compositions for increasing intestinal absorption of fats

A composition comprised of non-esterified fatty acids having 14-18 carbon atoms; monoglycerides which are monoesters of glycerol and fatty acids having 14-18 carbon atoms; lysophosphatidyl choline in which the fatty acid moiety has 14-18 carbon atoms and a drug is disclosed. The composition is useful for the delivery of orally-administered drugs. The composition is also useful as a source of readily absorbable fat. When used in this manner, the composition is comprised of non-esterified fatty acids having 14-18 carbon atoms; monoglycerides which are monoesters of glycerol and fatty acids having 14-18 carbon atoms; lysophosphatidyl choline in which the fatty acid moiety has 14-18 carbon atoms. A method of making the compositions disclosed is also described.

Composition for the delivery of orally administered drugs and other

A composition is disclosed containing nonesterified fatty acids having 14-22 carbon atoms of saturated, unsaturated and polyunsaturated fatty acid, monoglycerides which are monoesters of glycerol and fatty acids having 14-22 carbon atoms of saturated, unsaturated and polyunsaturated fatty acid, lysophosphatidylcholine in which the fatty acid moiety has 14-22 carbon atoms of saturated, unsaturated and polyunsaturated fatty acid and bicarbonate. The compositions can optionally also contain bile salts. These compositions form submicron size colloidal particles and can act as vehicles for transporting orally administered drugs, sources of calories in the form of readily absorbable and sustained absorption of fats, sources of readily absorbable polyunsaturated fat and as particles for topical application to the skin. A method of making these particles is also described.

Mixed Liped-Bicarbonate colloidal particles for delivering drugs or

A composition is disclosed containing non-esterified fatty acids having 14-18 carbon atoms, monoglycerides which are monoesters of glycerol and fatty acids having 14-18 carbon atoms, lysophosphatidylcholine in which the fatty acid moiety has 14-18 carbon atoms and bicarbonate. The compositions can optionally also contain bile salts. These compositions form submicron size colloidal particles and can act as vehicles for transporting orally administered drugs, sources of calories in the form of readily absorbable fats and as particles for topical application to the skin. A method of making these particles is also described.

Mixed lipid-bicarbonate colloidal particles for delivering drugs

Methods for making lysophosphatidylcholine are provided, comprising hydrolysis of a mixture of phosphatidylcholine and an agent with phospholipase A.sub.2. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride and fatty acid.

Methods for making lysophosphatidylcholine

A method of assessing the mixed lipid transport properties of a drug is provided. The method includes providing a mixed lipid composition which incorporates a drug in colloidal particles, applying the particles to a size exclusion chromatography column, eluting free drug and drug incorporated into mixed lipid particles from the column, and determining the elution profiles of the free drug and the drug incorporated into mixed lipid particles. Drugs which elute with the mixed lipid particles are considered to have stable transport properties when incorporated into the mixed lipid particles.

Method of accessing mixed lipid transport properties of a drug

A composition is disclosed containing nonesterified fatty acids having 14-18 carbon atoms, monoglycerides which are monoesters of glycerol and fatty acids having 14-18 carbon atoms, lysophosphatidylcholine in which the fatty acid moiety has 14-18 carbon atoms and bicarbonate. The compositions can optionally also contain bile salts. These compositions form submicron size colloidal particles and can act as vehicles for transporting orally administered drugs, sources of calories in the form of readily absorbable fats and as particles for topical application to the skin. A method of making these particles is also described.

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Byfield, MA, United States of America

David W Yesair