Millennium Pharmaceuticals Limited

Other

Millenium Pharmaceuticals, Inc.

Revolution Medicines, Inc.

Warp Drive Bio, Inc.

Bayer Healthcare Aktiengesellschaft

Ore Pharmaceuticals Inc.

David W White

Louis Anthony Tartaglia

Robert I Tepper

Janice A Culpepper

Gregory Lawrence Verdine

Rosana Kapeller-Libermann

David M Armistead

Brian Yichiun Chow

Mathew Edward Sowa

Deborah Palestrant

Chris K Varma

Kyle J MacBeth

Thomas M Barnes

Dominic Picarella

Robert Coopersmith

Omead Amidi

Immaculada Silos-Santiago

Scott Edward Malstrom

Shelley M White

Richard M Webb

James Ryan Miller

Timothy Dobbler

Keith E Robision

Disclosed herein are methods for identifying novel drug candidates.

Identifying new therapeutic agents

A method for treating an inflammatory disease of the digestive tract, for example inflammatory bowel disease, in a subject comprises administering to the subject a therapeutically effective amount of a compound selected from the group consisting of (S,S)-2- [1-carboxy-2-[3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl]-ethylamino]-4-methylpentanoic acid and pharmaceutically acceptable salts thereof.

Method for treating inflammatory diseases of the digestive tract

The present invention relates to the discovery, identification and characterization of nucleotides that encode Ob receptor (ObR), a receptor protein that participates in mammalian body weight regulation. The invention encompasses obR nucleotides, host cell expression systems, ObR proteins, fusion proteins, polypeptides and peptides, antibodies to the receptor, transgenic animals that express an obR transgene, or recombinant knock-out animals that do not express the ObR, antagonists and agonists of the receptor, and other compounds that modulate obR gene expression or ObR activity that can be used for diagnosis, drug screening, clinical trial monitoring, and/or the treatment of body weight disorders, including but not limited to obesity, cachexia and anorexia.

Methods for detection of the Ob receptor and the diagnosis of body weight disorders, including obesity and cachexia

A target apparatus for bola tossing games has both a forward and rearward frame presenting one or more rung-targets as well as a construction for the rung-targets by which such have free-spinning outer sleeves. Wherein the spacing between the forward and rearward changes the complexion of bola tossing games by adding a depth dimension among various ones of the rung-targets. And wherein the free-spinning aspect of the rung-targets increases the level of difficulty and skill in perching bolas, either wrapped or draped, at rest on rungs by not only increasing the propensity of landing bolas to, in quick succession, wind fully in and then on rebound unwind and thereafter self-launch off the subject rung but also by increasing the propensity that the foregoing dislodges any previously perched bola.

Target apparatus for bola toss game

The present invention relates to a newly identified human aminopeptidase. The invention also relates to polynucleotides encoding the aminopeptidase. The invention further relates to methods using the aminopeptidase polypeptides and polynucleotides as a target for diagnosis and treatment in aminopeptidase-related disorders. The invention further relates to drug-screening methods using the aminopeptidase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the aminopeptidase polypeptides and polynucleotides. The invention further relates to procedures for producing the aminopeptidase polypeptides and polynucleotides.

2786, a novel human aminopeptidase

Methods of using the OB receptor antibodies to treat bodyweight disorders

A system and method for implementing a wireless data transmission scheme through the use of a display capable of displaying symbolic information, a data acquisition device capable of identifying and capturing said displayed information and a mitigation device adapted to allow the data acquisition device to capture the symbolic information. The symbolic information may be a barcode displayed on an LCD outputting linearly polarized light. The data acquisition device may be a laser scanner, and the mitigation device may be a quarter wave retarder located between the display and the scanner. A larger system may utilize this wireless system or a different front end in a more generalized backend information transfer system. The backend system may include a centralized data center adapted to be used with retail couponing, ticketing, digital receipts, or a plurality of other information systems in which data is used separately from its storage location.

Scannable barcode display and methods for using the same

Chimeric proteins comprising the extracellular domain of murine Ob receptor

Human aminopeptidase

Ob receptor and methods for the diagnosis and treatment of body weight disorders

Methods of identifying compounds that modulate body weight using the OB receptor

Growing community of inventors

Holbrook, MA, United States of America

David W White